5 Citazioni (Scopus)

Abstract

The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA-EDA-C18derivatives (125 and 320 kDa) having ionic strength sensitive properties are synthesized and characterized. The control of the rheological properties of HA-EDA-C18aqueous dispersions by formation of inclusion complexes with hydroxypropyl-β-cyclodextrins (HPCD) is described. Reversibility of C18/HPCD complexation and physical crosslinking is detected in media with different ionic strength through oscillation frequency tests. HA-EDA-C18125 kDa is employed for nanogel fabrication. Control over nanogel dimension by flow ratio regulation is demonstrated. HA-EDA-C18320 kDa with HPCD is employed for fabrication of both microfibers and microchannels. Dimension of fibers is controlled by modulating flow ratios. Suitability for biological functionalization is assayed introducing cell adhesive peptides. Adhesion and encapsulation of human umbilical vein endothelial cells is evaluated.
Lingua originaleEnglish
pagine (da-a)1700265-
Numero di pagine10
RivistaMacromolecular Materials and Engineering
Volume302
Stato di pubblicazionePublished - 2017

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ethylenediamine
Hyaluronic acid
Hyaluronic Acid
Microfluidics
Derivatives
Cyclodextrins
Fabrication
Fibers
Ionic strength
Bearings (structural)
Endothelial cells
Microchannels
Complexation
Dispersions
Encapsulation
Crosslinking
Peptides
Adhesives
Adhesion
NanoGel

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

@article{f5497266af1c4bdbaa94a7f2f0c3b8e5,
title = "Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative",
abstract = "The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA-EDA-C18derivatives (125 and 320 kDa) having ionic strength sensitive properties are synthesized and characterized. The control of the rheological properties of HA-EDA-C18aqueous dispersions by formation of inclusion complexes with hydroxypropyl-{\^I}²-cyclodextrins (HPCD) is described. Reversibility of C18/HPCD complexation and physical crosslinking is detected in media with different ionic strength through oscillation frequency tests. HA-EDA-C18125 kDa is employed for nanogel fabrication. Control over nanogel dimension by flow ratio regulation is demonstrated. HA-EDA-C18320 kDa with HPCD is employed for fabrication of both microfibers and microchannels. Dimension of fibers is controlled by modulating flow ratios. Suitability for biological functionalization is assayed introducing cell adhesive peptides. Adhesion and encapsulation of human umbilical vein endothelial cells is evaluated.",
keywords = "Chemical Engineering (all), Materials Chemistry2506 Metals and Alloys, Organic Chemistry, Polymers and Plastics, cell encapsulation, hyaluronic acid, microchannels, microfibers, microfluidics, nanogels",
author = "{Di Bella}, {Maria Antonietta} and Palumbo, {Fabio Salvatore} and Stefano Agnello and Giovanna Pitarresi and Flavia Bongiov{\`i} and Gaetano Giammona and Calogero Fiorica and Gaetano Giammona",
year = "2017",
language = "English",
volume = "302",
pages = "1700265--",
journal = "Macromolecular Materials and Engineering",
issn = "1438-7492",
publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - Microfluidic Fabrication of Physically Assembled Nanogels and Micrometric Fibers by Using a Hyaluronic Acid Derivative

AU - Di Bella, Maria Antonietta

AU - Palumbo, Fabio Salvatore

AU - Agnello, Stefano

AU - Pitarresi, Giovanna

AU - Bongiovì, Flavia

AU - Giammona, Gaetano

AU - Fiorica, Calogero

AU - Giammona, Gaetano

PY - 2017

Y1 - 2017

N2 - The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA-EDA-C18derivatives (125 and 320 kDa) having ionic strength sensitive properties are synthesized and characterized. The control of the rheological properties of HA-EDA-C18aqueous dispersions by formation of inclusion complexes with hydroxypropyl-β-cyclodextrins (HPCD) is described. Reversibility of C18/HPCD complexation and physical crosslinking is detected in media with different ionic strength through oscillation frequency tests. HA-EDA-C18125 kDa is employed for nanogel fabrication. Control over nanogel dimension by flow ratio regulation is demonstrated. HA-EDA-C18320 kDa with HPCD is employed for fabrication of both microfibers and microchannels. Dimension of fibers is controlled by modulating flow ratios. Suitability for biological functionalization is assayed introducing cell adhesive peptides. Adhesion and encapsulation of human umbilical vein endothelial cells is evaluated.

AB - The employ of a hyaluronic acid (HA) derivative, bearing octadecyl (C18) and ethylenediamine (EDA) groups, for microfluidic fabrication of nanogels and microfibers is reported in this study. Two HA-EDA-C18derivatives (125 and 320 kDa) having ionic strength sensitive properties are synthesized and characterized. The control of the rheological properties of HA-EDA-C18aqueous dispersions by formation of inclusion complexes with hydroxypropyl-β-cyclodextrins (HPCD) is described. Reversibility of C18/HPCD complexation and physical crosslinking is detected in media with different ionic strength through oscillation frequency tests. HA-EDA-C18125 kDa is employed for nanogel fabrication. Control over nanogel dimension by flow ratio regulation is demonstrated. HA-EDA-C18320 kDa with HPCD is employed for fabrication of both microfibers and microchannels. Dimension of fibers is controlled by modulating flow ratios. Suitability for biological functionalization is assayed introducing cell adhesive peptides. Adhesion and encapsulation of human umbilical vein endothelial cells is evaluated.

KW - Chemical Engineering (all)

KW - Materials Chemistry2506 Metals and Alloys

KW - Organic Chemistry

KW - Polymers and Plastics

KW - cell encapsulation

KW - hyaluronic acid

KW - microchannels

KW - microfibers

KW - microfluidics

KW - nanogels

UR - http://hdl.handle.net/10447/250375

UR - http://www3.interscience.wiley.com/journal/117930403/grouphome/home.html

M3 - Article

VL - 302

SP - 1700265-

JO - Macromolecular Materials and Engineering

JF - Macromolecular Materials and Engineering

SN - 1438-7492

ER -