Microcirculation in the healing ofsurgical wounds in the oralcavity

Abstract. The aim of this research is to evaluate in vivo the characteristics ofmicrocirculation after taking a biopsy sample from the oral mucosa. 20 patientswere recruited to the study and all underwent an oral mucosa biopsy for the excisionof benign neoformations. The modifications in the oral microcirculation wereevaluated in vivo in correspondence to the surgical site through videocapillaroscopyat three different times: 30 min before the biopsy; 48 h after the biopsy; and 7 daysafter the biopsy. The statistical significance was checked with the Mann–WhitneyU-test (P < 0.05). The analysis of videocapillaroscopic patterns showedstatistically significant variations relative to the capillary loop density; the diameterof the outgoing loop; and the length of the capillary loop. In conclusion, the studydescribes a simple and reproducible model for the study of wound healing from amicrocirculatory point of view.