Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation

Clelia Dispenza, Clelia Dispenza, Daniela Giacomazza, Mats Jonsson

Risultato della ricerca: Articlepeer review

Abstract

Bio-hybrid hydrogels consist of a water-swollen hydrophilic polymer network encapsulating or conjugating single biomolecules, or larger and more complex biological constructs like whole cells. By modulating at least one dimension of the hydrogel system at the micro- or nanoscale, the activity of the biological component can be extremely upgraded with clear advantages for the development of therapeutic or diagnostic micro- and nano-devices. Gamma or e-beam irradiation of polymers allow a good control of the chemistry at the micro-/nanoscale with minimal recourse to toxic reactants and solvents. Another potential advantage is to obtain simultaneous sterilization when the absorbed doses are within the sterilization dose range. This short review will highlight opportunities and challenges of the radiation technologies to produce bio-hybrid nanogels as delivery devices of therapeutic biomolecules to the target cells, tissues, and organs, and to create hydrogel patterns at the nano-length and micro-length scales on surfaces.
Lingua originaleEnglish
pagine (da-a)47-
Numero di pagine19
RivistaBiomolecules
Volume11
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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