Micro-RNA in pancreatic adenocarcinoma: Predictive/prognostic biomarkers or therapeutic targets?

Antonio Russo, Alessandro Bittoni, Vito Lorusso, Stefano Cascinu, Oronzo Brunetti, Sabina Delcuratolo, Antonio Gnoni, Loredana Palermo, Michele Signorile, Aldo Scarpa, Amalia Azzariti, Giuseppe Aprile, Michele Reni, Nicola Silvestris, Daniele Santini, Daniele Santini

Risultato della ricerca: Article

45 Citazioni (Scopus)

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a tumor with a poor prognosis, short overall survival and few chemotherapeutic choices. Micro-RNAs (miRNAs) are noncoding, single-stranded RNAs of around 22 nucleotides involved in the pathogenic mechanisms of carcinogenesis and metastasis. They have been studied in many tumors in order to identify potential diagnostic, prognostic or therapeutic targets. In the current literature, many studies have analyzed the role of miRNAs in PDAC. In fact, the absence of appropriate biomarkers, the difficultly of early detection of this tumor, and the lack of effective chemotherapy in patients with unresectable disease have focused attention on miRNAs as new, interesting advance in this malignancy. In this review we analyzed the role of miRNAs in PDAC in order to understand the mechanisms of action and the difference between the onco-miRNA and the tumor suppressor miRNA. We also reviewed all the data related to the use of these molecules as predictive as well as prognostic biomarkers in the course of the disease. Finally, the possible therapeutic use of miRNAs or anti-miRNAs in PDAC is also discussed. In conclusion, although there is still no clinical application for these molecules in PDAC, it is our opinion that the preclinical evidence of the role of specific miRNAs in carcinogenesis, the possibility of using miRNAs as diagnostic or prognostic biomarkers, and their potential therapeutic role, warrant future studies in PDAC.
Lingua originaleEnglish
pagine (da-a)23323-23341
Numero di pagine19
RivistaOncotarget
Volume6
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Oncology

Fingerprint Entra nei temi di ricerca di 'Micro-RNA in pancreatic adenocarcinoma: Predictive/prognostic biomarkers or therapeutic targets?'. Insieme formano una fingerprint unica.

  • Cita questo

    Russo, A., Bittoni, A., Lorusso, V., Cascinu, S., Brunetti, O., Delcuratolo, S., Gnoni, A., Palermo, L., Signorile, M., Scarpa, A., Azzariti, A., Aprile, G., Reni, M., Silvestris, N., Santini, D., & Santini, D. (2015). Micro-RNA in pancreatic adenocarcinoma: Predictive/prognostic biomarkers or therapeutic targets? Oncotarget, 6, 23323-23341.