Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

Antonio Craxi, Calogero Camma', Salvatore Petta, Marco Barbara, Elisabetta Bugianesi, Luca Valenti, Silvia Fargion, Jacob George, Mohammed Eslam, Chiara Rosso, Marianna Porzio

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity (P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54 years) and visceral obesity (P=.04). In the lower (<41 years) and middle (41-54 years) age tertiles, the risk for F3-F4 fibrosis was mostly driven by visceral obesity and IFG/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (>54 years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52%-54%). Conclusions: Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.
Lingua originaleEnglish
pagine (da-a)1389-1396
Numero di pagine8
RivistaLiver International
Volume37
Stato di pubblicazionePublished - 2017

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Abdominal Obesity
Fibrosis
HDL Lipoproteins
LDL Lipoproteins
Obesity
Metabolome
LDL Cholesterol
HDL Cholesterol
Non-alcoholic Fatty Liver Disease
Triglycerides
Age Groups
Logistic Models
Regression Analysis
Hypertension
Biopsy
Liver

All Science Journal Classification (ASJC) codes

  • Hepatology

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Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study. / Craxi, Antonio; Camma', Calogero; Petta, Salvatore; Barbara, Marco; Bugianesi, Elisabetta; Valenti, Luca; Fargion, Silvia; George, Jacob; Eslam, Mohammed; Rosso, Chiara; Porzio, Marianna.

In: Liver International, Vol. 37, 2017, pag. 1389-1396.

Risultato della ricerca: Article

Craxi, A, Camma', C, Petta, S, Barbara, M, Bugianesi, E, Valenti, L, Fargion, S, George, J, Eslam, M, Rosso, C & Porzio, M 2017, 'Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study', Liver International, vol. 37, pagg. 1389-1396.
Craxi, Antonio ; Camma', Calogero ; Petta, Salvatore ; Barbara, Marco ; Bugianesi, Elisabetta ; Valenti, Luca ; Fargion, Silvia ; George, Jacob ; Eslam, Mohammed ; Rosso, Chiara ; Porzio, Marianna. / Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study. In: Liver International. 2017 ; Vol. 37. pagg. 1389-1396.
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title = "Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study",
abstract = "Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity (P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54{\^A} years) and visceral obesity (P=.04). In the lower (<41{\^A} years) and middle (41-54{\^A} years) age tertiles, the risk for F3-F4 fibrosis was mostly driven by visceral obesity and IFG/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (>54{\^A} years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52{\%}-54{\%}). Conclusions: Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.",
keywords = "diabetes; metabolic syndrome; nonalcoholic fatty liver disease; obesity; Hepatology",
author = "Antonio Craxi and Calogero Camma' and Salvatore Petta and Marco Barbara and Elisabetta Bugianesi and Luca Valenti and Silvia Fargion and Jacob George and Mohammed Eslam and Chiara Rosso and Marianna Porzio",
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TY - JOUR

T1 - Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

AU - Craxi, Antonio

AU - Camma', Calogero

AU - Petta, Salvatore

AU - Barbara, Marco

AU - Bugianesi, Elisabetta

AU - Valenti, Luca

AU - Fargion, Silvia

AU - George, Jacob

AU - Eslam, Mohammed

AU - Rosso, Chiara

AU - Porzio, Marianna

PY - 2017

Y1 - 2017

N2 - Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity (P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54 years) and visceral obesity (P=.04). In the lower (<41 years) and middle (41-54 years) age tertiles, the risk for F3-F4 fibrosis was mostly driven by visceral obesity and IFG/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (>54 years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52%-54%). Conclusions: Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.

AB - Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity (P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54 years) and visceral obesity (P=.04). In the lower (<41 years) and middle (41-54 years) age tertiles, the risk for F3-F4 fibrosis was mostly driven by visceral obesity and IFG/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (>54 years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52%-54%). Conclusions: Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.

KW - diabetes; metabolic syndrome; nonalcoholic fatty liver disease; obesity; Hepatology

UR - http://hdl.handle.net/10447/248064

UR - http://www.wiley.com/bw/journal.asp?ref=1478-3223

M3 - Article

VL - 37

SP - 1389

EP - 1396

JO - Liver International

JF - Liver International

SN - 1478-3223

ER -