Objective: GH replacement therapy in children with GH deficiency (GHD) mainly promotes lineargrowth. Not only have very few studies fully analyzed the metabolic consequences of GH therapy, butalso the question as to whether GH may affect adipokine secretion has been insufficiently investigated.Our aim was to study the effects of GH replacement therapy on auxological data, lipid and glycemicprofiles, insulin homeostasis (HOMA-IR) and serum adipokines in children.Methods: This was a 1-year prospective study. Thirty-four GHD children (11.6G2.6 years) and thirtyhealthy matched controls were enrolled. Children affected by GHD were studied both before beginningcontinuous GH replacement therapy and again at 12 months.Results: At the beginning of the study, total and LDL cholesterol were higher in GHD children than incontrols (P!0.001), whereas HDL cholesterol, triglycerides, insulin, HOMA-IR, leptin, andadiponectin were similar. At 12 months of continuous GH replacement therapy in the GHD group,there was a significant increase in both auxological data and IGF-I (P!0.001); total cholesterol(P!0.001), LDL (P!0.001), triglycerides (P!0.005), and leptin (P!0.001) decreased significantly;HDL (P!0.003), insulin (P!0.001), HOMA-IR (P!0.001) increased while adiponectin wasunmodified. Furthermore, IGF-ID showed an inverse correlation with leptin D (rZK0.398, PZ0.02).Conclusions: In GHD children, the evaluation of metabolic parameters proves to be a useful tool for theevaluation of auxological parameters during GH replacement therapy. In our study, GH replacementtherapy in GHD children improved final height, restored IGF-I levels, reduced leptin levels, andimproved the lipid profile, without producing any unfavorable effects on glucose metabolism.
|Numero di pagine||8|
|Rivista||European Journal of Endocrinology|
|Stato di pubblicazione||Published - 2007|
All Science Journal Classification (ASJC) codes