Although improvement in early diagnosis and treatment ameliorated life expectancy ofcancer patients, metastatic disease still lacks effective therapeutic approaches. Resistance to anticancertherapies stems from the refractoriness of a subpopulation of cancer cells—termed cancer stemcells (CSCs)—which is endowed with tumor initiation and metastasis formation potential. CSCsare heterogeneous and diverge by phenotypic, functional and metabolic perspectives. Intrinsicas well as extrinsic stimuli dictated by the tumor microenvironment (TME)have critical roles indetermining cell metabolic reprogramming from glycolytic toward an oxidative phenotype andvice versa, allowing cancer cells to thrive in adverse milieus. Crosstalk between cancer cells andthe surrounding microenvironment occurs through the interchange of metabolites, miRNAs andexosomes that drive cancer cells metabolic adaptation. Herein, we identify the metabolic nodes ofCSCs and discuss the latest advances in targeting metabolic demands of both CSCs and stromal cellswith the scope of improving current therapies and preventing cancer progression.
|Numero di pagine||27|
|Stato di pubblicazione||Published - 2020|
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