Mesenteric lymph node involvement in advanced ovarian cancer patients undergoing rectosigmoid resection: Prognostic role and clinical considerations

Vito Chiantera, Camilla Nero, Francesca Ciccarone, Salvatore Gueli Alletti, Giovanni Scambia, Francesco Legge, Alessandro Pasquale Margariti, Vito Chiantera, Francesco Fanfani, Sergio Alfieri, Anna Fagotti, Gabriella Ferrandina, Giovanni Scambia, Valerio Papa, Valerio Gallotta

Risultato della ricerca: Articlepeer review

14 Citazioni (Scopus)

Abstract

Background: The aim of this retrospective study was to investigate the incidence of mesenteric lymph node (MLN) involvement, and its prognostic role in advanced ovarian cancer (OC). Methods: OC patients undergoing rectosigmoid resection during primary debulking surgery or interval debulking surgery were recorded. Progression-free survival (PFS) and overall survival were calculated from the date of diagnosis to the date of relapse/progression, death of disease, or the date of last follow-up. Results: MLNs were detected in 102/148 cases (68.9 %); the rate of MLN involvement was 47.0 %. The percentage of metastatic MLNs was higher in cases with >5 MLNs removed compared with cases with ≤5 MLNs removed (62.7 % vs. 31.3 %; p = 0.0027). A progressive increase in the rate of metastatic MLNs was documented in association with depth of bowel infiltration (p = 0.026). Cases with metastatic MLNs experienced isolated celiac trunk or aortic lymph node recurrences more frequently than patients without MLN involvement (44.8 % vs. 10.7 %; p = 0.0008). PFS did not differ between cases with positive versus negative MLN involvement (2-year PFS = 31 % vs. 43 %; p = 0.58). Conclusion: OC patients undergoing rectosigmoid resection showed metastatic MLN involvement in 47.0 % of cases. Metastatic MLN status is associated with a high rate of isolated aortic and celiac trunk lymph node recurrences. © 2014 Society of Surgical Oncology.
Lingua originaleEnglish
pagine (da-a)2369-2375
Numero di pagine7
RivistaAnnals of Surgical Oncology
Volume21
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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