Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

Claudio Tripodo; Barbara Zavan; Vincenzo Vindigni; Giorgio Zauli; Paola Secchiero; Federica Corallini

Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

Claudio Tripodo, Barbara Zavan, Vincenzo Vindigni, Giorgio Zauli, Paola Secchiero, Federica Corallini

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

5 Citazioni (Scopus)

Abstract

A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

Lingua originale	English
Numero di pagine	5
Rivista	Investigational New Drugs
Stato di pubblicazione	Published - 2012

All Science Journal Classification (ASJC) codes

???subjectarea.asjc.2700.2730???
???subjectarea.asjc.3000.3004???
???subjectarea.asjc.2700.2736???

Altri file e collegamenti

OA Link

Cita questo

@article{b832695aaeaf4ee39c707c9b2b80d24e,

title = "Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.",

abstract = "A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.",

author = "Claudio Tripodo and Barbara Zavan and Vincenzo Vindigni and Giorgio Zauli and Paola Secchiero and Federica Corallini",

year = "2012",

language = "English",

journal = "Investigational New Drugs",

issn = "0167-6997",

publisher = "Kluwer Academic Publishers",

}

TY - JOUR

T1 - Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

AU - Tripodo, Claudio

AU - Zavan, Barbara

AU - Vindigni, Vincenzo

AU - Zauli, Giorgio

AU - Secchiero, Paola

AU - Corallini, Federica

PY - 2012

Y1 - 2012

N2 - A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

AB - A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.

UR - http://hdl.handle.net/10447/57801

M3 - Article

JO - Investigational New Drugs

JF - Investigational New Drugs

SN - 0167-6997

ER -

Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

Abstract

All Science Journal Classification (ASJC) codes

Altri file e collegamenti

Fingerprint

Cita questo