Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

Claudio Tripodo, Barbara Zavan, Vincenzo Vindigni, Giorgio Zauli, Paola Secchiero, Federica Corallini

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC. These data suggest that hyaluronan-embedded MSC exert anti-lymphoma activity by ameliorating hepatic functionality.
Lingua originaleEnglish
Numero di pagine5
RivistaInvestigational New Drugs
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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