MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease

Stefania Grimaudo, Claudio Tripodo, Rosaria Maria Pipitone, Salvatore Petta, Antonio Craxi, Calogero Camma', Alessandro Gulino, Raffaela Rametta, Fabio Marra, Andrea Cappon, Paola Dongiovanni, Enrico Mozzi, Elisabetta Bugianesi, Marco Maggioni, Luca Valenti, Silvia Fargion, Giovanni Di Maira, Emanuele Orlando

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Abstract

Homozygosity for a common non-coding rs4374383 G>A polymorphism in MERTK has been associated with protection against fibrosis progression in chronic hepatitis C. The main study objective was to assess whether MERTK AA genotype influences liver fibrosis, and secondarily MERTK expression in patients with NAFLD. We also investigated whether MERTK is expressed in human hepatic stellate cells (HSC) and in murine models of fibrogenesis.
Lingua originaleEnglish
Numero di pagine9
RivistaJournal of Hepatology
Stato di pubblicazionePublished - 2015

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All Science Journal Classification (ASJC) codes

  • Hepatology

Cita questo

Grimaudo, S., Tripodo, C., Pipitone, R. M., Petta, S., Craxi, A., Camma', C., Gulino, A., Rametta, R., Marra, F., Cappon, A., Dongiovanni, P., Mozzi, E., Bugianesi, E., Maggioni, M., Valenti, L., Fargion, S., Di Maira, G., & Orlando, E. (2015). MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease. Journal of Hepatology.