The literature on immunosenescence has focused mainly on T cell impairment. With the aimof gaining insight into B cell immunosenescence, the authors investigated the serum IgD levelsin 24 young and 21 old people and analyzed their relationship with the number ofCD19 CD27 memory cells. Serum IgD were quantified by the use of radial immunodiffusionand the lymphocyte population CD19 CD27 was identified by a FACScan flow cytometer.Serum IgD levels were significantly lower (p 0.0001) in old subjects, and the percentageof CD19 CD27 lymphocytes were significantly increased (p 0.01) in old subjects.Finally, a significant negative correlation was found (p 0.01) between serum concentrationsof IgD and CD19 CD27 . The present results show that the levels of IgD are negatively agerelatedto the amount of B memory cells. This suggests that the B repertoire available to respondto new antigenic challenges is decreased in the elderly also. In fact, many memoryIgD B cells fill immunologic space, and the number of naïve IgD B cells is dramaticallydecreased. Therefore, these preliminary results suggest that a decrease of naïve IgD CD27 B cells and a concomitant increase of memory IgD CD27 B cells could represent hallmarksof B immunosenescence, might provide biomarkers related to the lifespan of humans, andcould be useful for the evaluation of antiaging treatments.
|Numero di pagine||4|
|Stato di pubblicazione||Published - 2006|
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