Membrane vesicles containingmatrix metalloproteinase-9 andfibroblast growth factor-2 arereleased into the extracellularspace from mouse mesoangioblast Sstem cells

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Abstract

Certain proteins, including fibroblast growth factor-2 (FGF-2) and matrixmetalloproteinase-9 (MMP-9), have proved very effective in increasing theefficacy of mesoangioblast stem cell therapy in repairing damaged tissue. Weprovide the first evidence that mouse mesoangioblast stem cells release FGF-2 andMMP-9 in their active form through the production of membrane vesicles. Thesevesicles are produced and turned over continuously, but are stable for some time in the extracellular milieu. Mesoangioblasts shed membrane vesicles even underoxygen tensions that are lower than those typically used for cell culture andmore like those of mouse tissues. These findings suggest that mesoangioblasts maythemselves secrete paracrine signals and factors that make damaged tissues moreamenable to cell therapy through the release of membrane vesicles.
Lingua originaleEnglish
Numero di pagine7
RivistaJournal of Cellular Physiology
Volume224
Stato di pubblicazionePublished - 2010

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1300.1307???

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