TY - JOUR
T1 - Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications
AU - Ventura Spagnolo, Elvira
AU - Gualniera, Patrizia
AU - Sapienza, Daniela
AU - Scurria, Serena
AU - Mondello, Cristina
AU - Cardia, Luigi
AU - Asmundo, Alessio
AU - Scurria, Salvatore
PY - 2020
Y1 - 2020
N2 - The complement system has a significant role in myocardial ischemia/reperfusion injury,being responsible for cell lysis and amplification of inflammatory response. In this context, several studieshighlight that terminal complement complex C5b-9, also known as the membrane attack complex(MAC), is a significant contributor. The MAC functions were studied by many researchers analyzingthe characteristics of its activation in myocardial infarction. Here, a systematic literature reviewwas reported to evaluate the principal features, advantages, and limits (regarding the application)of complement components andMAC in post mortem settings to perform the diagnosis of myocardialischemia/infarction. The review was performed according to specific inclusion and exclusion criteria,and a total of 26 studies were identified. Several methods studiedMAC, and each study contributes todefining better howandwhen it affects themyocardial damage in ischemic/reperfusion injury. The articleswere discussed, focusing on the specificity, sensibility, and post mortem stability ofMAC as a marker ofmyocardial ischemia/infarction, supporting the usefulness in routine post mortem investigations
AB - The complement system has a significant role in myocardial ischemia/reperfusion injury,being responsible for cell lysis and amplification of inflammatory response. In this context, several studieshighlight that terminal complement complex C5b-9, also known as the membrane attack complex(MAC), is a significant contributor. The MAC functions were studied by many researchers analyzingthe characteristics of its activation in myocardial infarction. Here, a systematic literature reviewwas reported to evaluate the principal features, advantages, and limits (regarding the application)of complement components andMAC in post mortem settings to perform the diagnosis of myocardialischemia/infarction. The review was performed according to specific inclusion and exclusion criteria,and a total of 26 studies were identified. Several methods studiedMAC, and each study contributes todefining better howandwhen it affects themyocardial damage in ischemic/reperfusion injury. The articleswere discussed, focusing on the specificity, sensibility, and post mortem stability ofMAC as a marker ofmyocardial ischemia/infarction, supporting the usefulness in routine post mortem investigations
UR - http://hdl.handle.net/10447/438747
M3 - Article
SN - 2075-4418
VL - 10
SP - 1
EP - 18
JO - Diagnostics
JF - Diagnostics
ER -