Membrane Attack Complex in Myocardial Ischemia/Reperfusion Injury: A Systematic Review for Post Mortem Applications

Elvira Ventura Spagnolo, Adam Asmundo, Salvatore Scurria

Risultato della ricerca: Articlepeer review

Abstract

The complement system has a significant role in myocardial ischemia/reperfusion injury,being responsible for cell lysis and amplification of inflammatory response. In this context, several studieshighlight that terminal complement complex C5b-9, also known as the membrane attack complex(MAC), is a significant contributor. The MAC functions were studied by many researchers analyzingthe characteristics of its activation in myocardial infarction. Here, a systematic literature reviewwas reported to evaluate the principal features, advantages, and limits (regarding the application)of complement components andMAC in post mortem settings to perform the diagnosis of myocardialischemia/infarction. The review was performed according to specific inclusion and exclusion criteria,and a total of 26 studies were identified. Several methods studiedMAC, and each study contributes todefining better howandwhen it affects themyocardial damage in ischemic/reperfusion injury. The articleswere discussed, focusing on the specificity, sensibility, and post mortem stability ofMAC as a marker ofmyocardial ischemia/infarction, supporting the usefulness in routine post mortem investigations
Lingua originaleEnglish
pagine (da-a)1-18
Numero di pagine18
RivistaDiagnostics
Volume10
Stato di pubblicazionePublished - 2020

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