Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite

Pasquale Agozzino, Maria Antonia Livrea, Luisa Tesoriere, Leopoldo Ceraulo, David Bongiorno, Giuseppe Avellone, Maria C. Natoli, Pasquale Agozzino, Felice Filizzola, David Bongiorno, Leopoldo Ceraulo, Luisa Tesoriere, Giuseppe Avellone, Maria A. Livrea, Felice Filizzola, Maria Concetta Natoli

Risultato della ricerca: Article

23 Citazioni (Scopus)

Abstract

Oxidation of melatonin by Fenton reagents as well as with hypochlorous acid or oxoferryl hemoglobin has been investigated. Analysis of products by low resolution/mass spectra (MS), high resolution/MS, 1H-nuclear magnetic resonance (NMR), 13C-NMR, correlated spectroscopy (COSY) and heterocorrelated spectroscopy (HETCOR) 2D NMR reveals the formation of a single mono-oxygenated product under all conditions and unequivocally assigns the N-[2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide structure, which had not been previously considered.
Lingua originaleEnglish
pagine (da-a)269-275
Numero di pagine7
RivistaDefault journal
Volume35
Stato di pubblicazionePublished - 2003

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Melatonin
Magnetic Resonance Spectroscopy
Hypochlorous Acid
Hemoglobins

All Science Journal Classification (ASJC) codes

  • Endocrinology

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Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite. / Agozzino, Pasquale; Livrea, Maria Antonia; Tesoriere, Luisa; Ceraulo, Leopoldo; Bongiorno, David; Avellone, Giuseppe; Natoli, Maria C.; Agozzino, Pasquale; Filizzola, Felice; Bongiorno, David; Ceraulo, Leopoldo; Tesoriere, Luisa; Avellone, Giuseppe; Livrea, Maria A.; Filizzola, Felice; Natoli, Maria Concetta.

In: Default journal, Vol. 35, 2003, pag. 269-275.

Risultato della ricerca: Article

Agozzino, P, Livrea, MA, Tesoriere, L, Ceraulo, L, Bongiorno, D, Avellone, G, Natoli, MC, Agozzino, P, Filizzola, F, Bongiorno, D, Ceraulo, L, Tesoriere, L, Avellone, G, Livrea, MA, Filizzola, F & Natoli, MC 2003, 'Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite', Default journal, vol. 35, pagg. 269-275.
Agozzino P, Livrea MA, Tesoriere L, Ceraulo L, Bongiorno D, Avellone G e altri. Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite. Default journal. 2003;35:269-275.
Agozzino, Pasquale ; Livrea, Maria Antonia ; Tesoriere, Luisa ; Ceraulo, Leopoldo ; Bongiorno, David ; Avellone, Giuseppe ; Natoli, Maria C. ; Agozzino, Pasquale ; Filizzola, Felice ; Bongiorno, David ; Ceraulo, Leopoldo ; Tesoriere, Luisa ; Avellone, Giuseppe ; Livrea, Maria A. ; Filizzola, Felice ; Natoli, Maria Concetta. / Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite. In: Default journal. 2003 ; Vol. 35. pagg. 269-275.
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AU - Agozzino, Pasquale

AU - Livrea, Maria Antonia

AU - Tesoriere, Luisa

AU - Ceraulo, Leopoldo

AU - Bongiorno, David

AU - Avellone, Giuseppe

AU - Natoli, Maria C.

AU - Agozzino, Pasquale

AU - Filizzola, Felice

AU - Bongiorno, David

AU - Ceraulo, Leopoldo

AU - Tesoriere, Luisa

AU - Avellone, Giuseppe

AU - Livrea, Maria A.

AU - Filizzola, Felice

AU - Natoli, Maria Concetta

PY - 2003

Y1 - 2003

N2 - Oxidation of melatonin by Fenton reagents as well as with hypochlorous acid or oxoferryl hemoglobin has been investigated. Analysis of products by low resolution/mass spectra (MS), high resolution/MS, 1H-nuclear magnetic resonance (NMR), 13C-NMR, correlated spectroscopy (COSY) and heterocorrelated spectroscopy (HETCOR) 2D NMR reveals the formation of a single mono-oxygenated product under all conditions and unequivocally assigns the N-[2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide structure, which had not been previously considered.

AB - Oxidation of melatonin by Fenton reagents as well as with hypochlorous acid or oxoferryl hemoglobin has been investigated. Analysis of products by low resolution/mass spectra (MS), high resolution/MS, 1H-nuclear magnetic resonance (NMR), 13C-NMR, correlated spectroscopy (COSY) and heterocorrelated spectroscopy (HETCOR) 2D NMR reveals the formation of a single mono-oxygenated product under all conditions and unequivocally assigns the N-[2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide structure, which had not been previously considered.

KW - 1D and 2D nuclear magnetic resonance

KW - Endocrinology

KW - Mass spectra

KW - Melatonin

KW - Metabolites

KW - Structure

UR - http://hdl.handle.net/10447/243627

M3 - Article

VL - 35

SP - 269

EP - 275

JO - Default journal

JF - Default journal

ER -

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