Melatonin: Structural characterization of its non-enzymatic mono-oxygenate metabolite

Maria Antonia Livrea, Luisa Tesoriere, David Bongiorno, Leopoldo Ceraulo, Pasquale Agozzino, Giuseppe Avellone, Maria C. Natoli, Pasquale Agozzino, Felice Filizzola, David Bongiorno, Leopoldo Ceraulo, Luisa Tesoriere, Giuseppe Avellone, Maria A. Livrea, Felice Filizzola, Maria Concetta Natoli

Risultato della ricerca: Articlepeer review

23 Citazioni (Scopus)

Abstract

Oxidation of melatonin by Fenton reagents as well as with hypochlorous acid or oxoferryl hemoglobin has been investigated. Analysis of products by low resolution/mass spectra (MS), high resolution/MS, 1H-nuclear magnetic resonance (NMR), 13C-NMR, correlated spectroscopy (COSY) and heterocorrelated spectroscopy (HETCOR) 2D NMR reveals the formation of a single mono-oxygenated product under all conditions and unequivocally assigns the N-[2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide structure, which had not been previously considered.
Lingua originaleEnglish
pagine (da-a)269-275
Numero di pagine7
RivistaJournal of Pineal Research
Volume35
Stato di pubblicazionePublished - 2003

All Science Journal Classification (ASJC) codes

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