Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid

Mario Allegra, Maria Antonia Livrea, Luisa Tesoriere, Christian Obinger, Walter Jantschko, Paul Georg Furtmüller, Martina Zederbauer

Risultato della ricerca: Articlepeer review

63 Citazioni (Scopus)

Abstract

Production of nitrogen dioxide by the activity of myeloperoxidase (MPO) in the presence of nitrite is now considered a key step in the pathophysiology of low-density lipoprotein (LDL) oxidation. This study shows that betanin, a phytochemical of the betalain class, inhibits the production of lipid hydroperoxides in human LDL submitted to a MPO/nitrite-induced oxidation. Kinetic measurements including time-course of particle oxidation and betanin consumption, either in the presence or in the absence of nitrite, suggest that the antioxidant effect is possibly the result of various actions. Betanin scavenges the initiator radical nitrogen dioxide and can also act as a lipoperoxyl radical-scavenger. In addition, unidentified oxidation product(s) of betanin by MPO/nitrite inhibit(s) the MPO/nitrite-induced LDL oxidation as effectively as the parent compound. In the light of betanin bioavailability and post-absorbtion distribution in humans, present findings may suggest favourable in vivo activity of this phytochemical.
Lingua originaleEnglish
pagine (da-a)837-844
Numero di pagine8
RivistaBiochemical and Biophysical Research Communications
Volume332
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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