MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link

Francesco Cappello, Leila Zummo, Giovanni Li Li Volti, Cristoforo Pomara, D'Errico

Risultato della ricerca: Article

4 Citazioni (Scopus)

Abstract

Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs (“molecular chaperones”) in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic administration of MDMA.
Lingua originaleEnglish
pagine (da-a)496-499
Numero di pagine4
RivistaCurrent Pharmaceutical Biotechnology
Volume11
Stato di pubblicazionePublished - 2010

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N-Methyl-3,4-methylenedioxyamphetamine
Heat-Shock Response
Heat-Shock Proteins
Molecular Chaperones
Brain

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Pharmaceutical Science

Cita questo

MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link. / Cappello, Francesco; Zummo, Leila; Li Volti, Giovanni Li; Pomara, Cristoforo; D'Errico.

In: Current Pharmaceutical Biotechnology, Vol. 11, 2010, pag. 496-499.

Risultato della ricerca: Article

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