Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study

Fortunato Siracusa, Paolo D'Angelo, Alessandro Inserra, Patrizia Dall' Igna, Gian Luca Babbo, Fortunato Siracusa, Giovanna Riccipetitoni, Monica Terenziani, Maria Debora De Pasquale, Paolo Indolfi, Gianni Bisogno, Luigi Piva, Paolo Tamaro, Filippo Spreafico, Giovanni Cecchetto, Renata Boldrini, Massimo Conte

    Risultato della ricerca: Article

    17 Citazioni (Scopus)

    Abstract

    Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocolfor malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with amalignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a secondmetachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions. Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery inimmature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.
    Lingua originaleEnglish
    pagine (da-a)13-19
    Numero di pagine7
    RivistaPEDIATRIC BLOOD & CANCER
    Volume1
    Stato di pubblicazionePublished - 2015

    Fingerprint

    Teratoma
    Pediatrics
    Recurrence
    Germ Cell and Embryonal Neoplasms
    Cellular Structures
    Neuroblastoma
    Germ Cells
    Neoplasms
    Survival Rate

    All Science Journal Classification (ASJC) codes

    • Pediatrics, Perinatology, and Child Health
    • Hematology
    • Oncology

    Cita questo

    Siracusa, F., D'Angelo, P., Inserra, A., Dall' Igna, P., Babbo, G. L., Siracusa, F., ... Conte, M. (2015). Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study. PEDIATRIC BLOOD & CANCER, 1, 13-19.

    Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study. / Siracusa, Fortunato; D'Angelo, Paolo; Inserra, Alessandro; Dall' Igna, Patrizia; Babbo, Gian Luca; Siracusa, Fortunato; Riccipetitoni, Giovanna; Terenziani, Monica; De Pasquale, Maria Debora; Indolfi, Paolo; Bisogno, Gianni; Piva, Luigi; Tamaro, Paolo; Spreafico, Filippo; Cecchetto, Giovanni; Boldrini, Renata; Conte, Massimo.

    In: PEDIATRIC BLOOD & CANCER, Vol. 1, 2015, pag. 13-19.

    Risultato della ricerca: Article

    Siracusa, F, D'Angelo, P, Inserra, A, Dall' Igna, P, Babbo, GL, Siracusa, F, Riccipetitoni, G, Terenziani, M, De Pasquale, MD, Indolfi, P, Bisogno, G, Piva, L, Tamaro, P, Spreafico, F, Cecchetto, G, Boldrini, R & Conte, M 2015, 'Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study', PEDIATRIC BLOOD & CANCER, vol. 1, pagg. 13-19.
    Siracusa F, D'Angelo P, Inserra A, Dall' Igna P, Babbo GL, Siracusa F e altri. Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study. PEDIATRIC BLOOD & CANCER. 2015;1:13-19.
    Siracusa, Fortunato ; D'Angelo, Paolo ; Inserra, Alessandro ; Dall' Igna, Patrizia ; Babbo, Gian Luca ; Siracusa, Fortunato ; Riccipetitoni, Giovanna ; Terenziani, Monica ; De Pasquale, Maria Debora ; Indolfi, Paolo ; Bisogno, Gianni ; Piva, Luigi ; Tamaro, Paolo ; Spreafico, Filippo ; Cecchetto, Giovanni ; Boldrini, Renata ; Conte, Massimo. / Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study. In: PEDIATRIC BLOOD & CANCER. 2015 ; Vol. 1. pagg. 13-19.
    @article{9e8f1685f3504c609a6acc79e1358fcd,
    title = "Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study",
    abstract = "Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the {\circledR}rst Italian study, we collected cases of teratoma, alongside the protocolfor malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi{\circledR}ed according to the WHO classi{\circledR}cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with amalignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85{\%} and 9{\%} of cases. Seventeen events occurred: six females had a secondmetachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6{\%}, 94.3{\%}, 98.6{\%}, respectively. Conclusions. Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery inimmature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.",
    author = "Fortunato Siracusa and Paolo D'Angelo and Alessandro Inserra and {Dall' Igna}, Patrizia and Babbo, {Gian Luca} and Fortunato Siracusa and Giovanna Riccipetitoni and Monica Terenziani and {De Pasquale}, {Maria Debora} and Paolo Indolfi and Gianni Bisogno and Luigi Piva and Paolo Tamaro and Filippo Spreafico and Giovanni Cecchetto and Renata Boldrini and Massimo Conte",
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    language = "English",
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    pages = "13--19",
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    issn = "1545-5017",

    }

    TY - JOUR

    T1 - Mature and Immature Teratoma: A Report From the Second Italian Pediatric Study

    AU - Siracusa, Fortunato

    AU - D'Angelo, Paolo

    AU - Inserra, Alessandro

    AU - Dall' Igna, Patrizia

    AU - Babbo, Gian Luca

    AU - Siracusa, Fortunato

    AU - Riccipetitoni, Giovanna

    AU - Terenziani, Monica

    AU - De Pasquale, Maria Debora

    AU - Indolfi, Paolo

    AU - Bisogno, Gianni

    AU - Piva, Luigi

    AU - Tamaro, Paolo

    AU - Spreafico, Filippo

    AU - Cecchetto, Giovanni

    AU - Boldrini, Renata

    AU - Conte, Massimo

    PY - 2015

    Y1 - 2015

    N2 - Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocolfor malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with amalignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a secondmetachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions. Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery inimmature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.

    AB - Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocolfor malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with amalignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primary sites involved were: 118 gonadal and 101 extragonadal teratomas. Two females with ovarian teratoma had a positive family history. Complete and incomplete surgeries were performed in 85% and 9% of cases. Seventeen events occurred: six females had a secondmetachronous tumor (5 contralateral ovarian teratoma, 1 adrenal neuroblastoma) and 11 teratomas relapsed/progressed (3 mature, 8 immature teratomas). Two patients died, one of progressive immature teratoma and one of surgical complications. At a median follow up of 68 months, the event-free, relapse-free, and overall survival rates were 90.6%, 94.3%, 98.6%, respectively. Conclusions. Teratomas show a good prognosis, especially the mature ones: surgery and follow-up remain the standard approach. Incomplete surgery inimmature teratoma is the group at greatest risk of relapse. Bilateral ovarian tumors are a possibility, and the rare family predisposition to ovarian mature teratoma warrants further analyses.

    UR - http://hdl.handle.net/10447/107348

    M3 - Article

    VL - 1

    SP - 13

    EP - 19

    JO - PEDIATRIC BLOOD & CANCER

    JF - PEDIATRIC BLOOD & CANCER

    SN - 1545-5017

    ER -