Matrix metalloproteinases 2 and 9 and extracellular matrix in Kaposi’s Sarcoma

Aricò, M

Risultato della ricerca: Article

10 Citazioni (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered. However, MMPs 2 and 9 have been associated with different phases of angiogenesis, but their role in the proteolytic modification of the extracellular matrix has not been investigated. The results of this study confirm that MMPs, specifically MMP-2 and MMP-9, can contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaDermatologic Therapy
Volume2010
Stato di pubblicazionePublished - 2010

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Kaposi's Sarcoma
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Extracellular Matrix
Basement Membrane
Cell Movement
Carcinogenesis
Endothelial Cells
Growth

All Science Journal Classification (ASJC) codes

  • Dermatology

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Matrix metalloproteinases 2 and 9 and extracellular matrix in Kaposi’s Sarcoma. / Aricò, M.

In: Dermatologic Therapy, Vol. 2010, 2010, pag. -.

Risultato della ricerca: Article

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abstract = "Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered. However, MMPs 2 and 9 have been associated with different phases of angiogenesis, but their role in the proteolytic modification of the extracellular matrix has not been investigated. The results of this study confirm that MMPs, specifically MMP-2 and MMP-9, can contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues.",
keywords = "matrix metalloproteinase- 2; matrix metalloproteinase-9; sarcoma of Kaposi",
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AU - Aricò, M

AU - Arico', Mario

AU - Bongiorno, Maria Rita

AU - Ferro, Giuseppe

AU - Doukaki, Spyridoula

PY - 2010

Y1 - 2010

N2 - Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered. However, MMPs 2 and 9 have been associated with different phases of angiogenesis, but their role in the proteolytic modification of the extracellular matrix has not been investigated. The results of this study confirm that MMPs, specifically MMP-2 and MMP-9, can contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues.

AB - Matrix metalloproteinases (MMPs) are associated with Kaposi's sarcoma (KS) tumorigenesis and may contribute to the mechanism of KS invasive growth. To date, only a few MMPs have been studied in KS lesions, and exactly which MMPs are involved in KS development and progression remains unanswered. However, MMPs 2 and 9 have been associated with different phases of angiogenesis, but their role in the proteolytic modification of the extracellular matrix has not been investigated. The results of this study confirm that MMPs, specifically MMP-2 and MMP-9, can contribute to angiogenesis by disrupting the vessel basement membrane and other extracellular matrix barriers, and enabling endothelial cells migration through the surrounding tissues.

KW - matrix metalloproteinase- 2; matrix metalloproteinase-9; sarcoma of Kaposi

UR - http://hdl.handle.net/10447/44075

M3 - Article

VL - 2010

SP - -

JO - Dermatologic Therapy

JF - Dermatologic Therapy

SN - 1396-0296

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