MATRICES OF A HYDROPHOBICALLY FUNCTIONALIZED HYALURONIC ACID DERIVATIVE FOR THE LOCOREGIONAL TUMOUR TREATMENT

Fabio Salvatore Palumbo, Giovanna Pitarresi, Gaetano Giammona, Calogero Fiorica, Giovanni Cassata, Roberto Puleio, Giovanna Pitarresi, Guido Ruggero Loria, Gaetano Giammona

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

A hyaluronic acid (HA) derivative bearing octadecylamine and acylhydrazine functionalities has been here employed for the production of a paclitaxel delivering matrix for locoregional chemotherapy.Through a strategy consisting in a powder compression and a plasticization with a mixture water/ethanol, a physically assembled biomaterial, stable in solutions with physiologic ionic strengths, has been produced. Two different drug loading strategies have been adopted, by using paclitaxel as chemotherapic agent, and obtained samples have been assayed in terms of release in enhanced solubility conditions and in vitro and in vivo tumoural cytotoxicity. In particular sample with the best releasing characteristics was chosen for an in vivo evaluation against a HCT-116 xenograft on mice. Local tumour establishment and metastatic diffusion was assayed locally at the site of xenograft implantation and at the tributary lymphnodes. Obtained results demonstrated how loading procedure influenced paclitaxel crystallinity into the matrix and consequently drug diffusion and its cytoreductive potential. Chosen paclitaxel loaded matrixwas able to drastically inhibit HCT-116 establishment and metastatic diffusion.
Lingua originaleEnglish
pagine (da-a)205-215
Numero di pagine11
RivistaActa Biomaterialia
Volume25
Stato di pubblicazionePublished - 2015

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Hyaluronic acid
Hyaluronic Acid
Paclitaxel
Tumors
Derivatives
Bearings (structural)
Heterografts
Neoplasms
Chemotherapy
Cytotoxicity
Ionic strength
Biomaterials
Biocompatible Materials
Compaction
Ethanol
Therapeutics
Solubility
Pharmaceutical Preparations
Powders
Osmolar Concentration

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Medicine(all)

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MATRICES OF A HYDROPHOBICALLY FUNCTIONALIZED HYALURONIC ACID DERIVATIVE FOR THE LOCOREGIONAL TUMOUR TREATMENT. / Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Giammona, Gaetano; Fiorica, Calogero; Cassata, Giovanni; Puleio, Roberto; Pitarresi, Giovanna; Loria, Guido Ruggero; Giammona, Gaetano.

In: Acta Biomaterialia, Vol. 25, 2015, pag. 205-215.

Risultato della ricerca: Article

Palumbo, Fabio Salvatore ; Pitarresi, Giovanna ; Giammona, Gaetano ; Fiorica, Calogero ; Cassata, Giovanni ; Puleio, Roberto ; Pitarresi, Giovanna ; Loria, Guido Ruggero ; Giammona, Gaetano. / MATRICES OF A HYDROPHOBICALLY FUNCTIONALIZED HYALURONIC ACID DERIVATIVE FOR THE LOCOREGIONAL TUMOUR TREATMENT. In: Acta Biomaterialia. 2015 ; Vol. 25. pagg. 205-215.
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abstract = "A hyaluronic acid (HA) derivative bearing octadecylamine and acylhydrazine functionalities has been here employed for the production of a paclitaxel delivering matrix for locoregional chemotherapy.Through a strategy consisting in a powder compression and a plasticization with a mixture water/ethanol, a physically assembled biomaterial, stable in solutions with physiologic ionic strengths, has been produced. Two different drug loading strategies have been adopted, by using paclitaxel as chemotherapic agent, and obtained samples have been assayed in terms of release in enhanced solubility conditions and in vitro and in vivo tumoural cytotoxicity. In particular sample with the best releasing characteristics was chosen for an in vivo evaluation against a HCT-116 xenograft on mice. Local tumour establishment and metastatic diffusion was assayed locally at the site of xenograft implantation and at the tributary lymphnodes. Obtained results demonstrated how loading procedure influenced paclitaxel crystallinity into the matrix and consequently drug diffusion and its cytoreductive potential. Chosen paclitaxel loaded matrixwas able to drastically inhibit HCT-116 establishment and metastatic diffusion.",
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AU - Palumbo, Fabio Salvatore

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

AU - Fiorica, Calogero

AU - Cassata, Giovanni

AU - Puleio, Roberto

AU - Pitarresi, Giovanna

AU - Loria, Guido Ruggero

AU - Giammona, Gaetano

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AB - A hyaluronic acid (HA) derivative bearing octadecylamine and acylhydrazine functionalities has been here employed for the production of a paclitaxel delivering matrix for locoregional chemotherapy.Through a strategy consisting in a powder compression and a plasticization with a mixture water/ethanol, a physically assembled biomaterial, stable in solutions with physiologic ionic strengths, has been produced. Two different drug loading strategies have been adopted, by using paclitaxel as chemotherapic agent, and obtained samples have been assayed in terms of release in enhanced solubility conditions and in vitro and in vivo tumoural cytotoxicity. In particular sample with the best releasing characteristics was chosen for an in vivo evaluation against a HCT-116 xenograft on mice. Local tumour establishment and metastatic diffusion was assayed locally at the site of xenograft implantation and at the tributary lymphnodes. Obtained results demonstrated how loading procedure influenced paclitaxel crystallinity into the matrix and consequently drug diffusion and its cytoreductive potential. Chosen paclitaxel loaded matrixwas able to drastically inhibit HCT-116 establishment and metastatic diffusion.

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