Mast Cells Control the Expansion and Differentiation of IL-10-Competent B Cells.

Carla Guarnotta, Claudio Tripodo, Carla Guarnotta, Barbara Toffoletto, Alessia Burocchi, Alice Rigoni, Francesca Mion, Federica D'Incà, Luca Danelli, Claudio Tripodo, Barbara Frossi, Esther Lutgens, Norbert Gerdes, Carlo E. Pucillo, Gaetano Vitale, Juan Rivera, Mario P. Colombo

Risultato della ricerca: Articlepeer review

21 Citazioni (Scopus)

Abstract

The discovery of B cell subsets with regulatory properties, dependent on IL-10 production, has expanded our view on the mechanisms that control inflammation. Regulatory B cells acquire the ability to produce IL-10 in a stepwise process: first, they become IL-10 competent, a poised state in which B cells are sensitive to trigger signals but do not actually express the Il-10 gene; then, when exposed to appropriate stimuli, they start producing IL-10. Even if the existence of IL-10-competent B cells is now well established, it is not yet known how different immune cell types cross talk with B cells and affect IL-10-competent B cell differentiation and expansion. Mast cells (MCs) contribute to the differentiation and influence the effector functions of various immune cells, including B lymphocytes. In this study, we explored whether MCs could play a role in the expansion of IL-10-competent B cells and addressed the in vivo relevance of MC deficiency on the generation of these cells. We show that MCs can expand IL-10-competent B cells, but they do not directly induce IL-10 production; moreover, the absence of MCs negatively affects IL-10-competent B cell differentiation. Noteworthy, our findings reveal that the CD40L/CD40 axis plays a significant role in MC-driven expansion of IL-10-competent B cells in vitro and highlight the importance of MC CD40L signaling in the colon.
Lingua originaleEnglish
Numero di pagine0
RivistaJournal of Immunology
Volume00
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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