TY - JOUR
T1 - Management of Venous ThromboEmbolism in patients with acute leukemia at high bleeding risk: a multicenter study
AU - Siragusa, Sergio
AU - Napolitano, Mariasanta
AU - Casuccio, Alessandra
AU - Malato, Alessandra
AU - Lucchesi, Alessandro
AU - Mannina, Donato
AU - Vetro, Calogero
AU - Candoni, Anna
AU - Del Principe, Maria Ilaria
AU - Fabbiano, Francesco
AU - Di Raimondo, Francesco
PY - 2015
Y1 - 2015
N2 - In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
AB - In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
KW - Acute leukemia
KW - Low Molecular Weight Heparin
KW - Venous Thrombosis
KW - Acute leukemia
KW - Low Molecular Weight Heparin
KW - Venous Thrombosis
UR - http://hdl.handle.net/10447/127723
M3 - Article
SP - 1-13-13
JO - LEUKEMIA & LYMPHOMA
JF - LEUKEMIA & LYMPHOMA
SN - 1042-8194
ER -