Abstract
In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
| Lingua originale | English |
|---|---|
| pagine (da-a) | 1-13-13 |
| Numero di pagine | 13 |
| Rivista | LEUKEMIA & LYMPHOMA |
| Stato di pubblicazione | Published - 2015 |
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All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
- Cancer Research
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Napolitano, M., Casuccio, A., Siragusa, S., Malato, A., Lucchesi, A., Mannina, D., Vetro, C., Candoni, A., Del Principe, M. I., Fabbiano, F., & Di Raimondo, F. (2015). Management of Venous ThromboEmbolism in patients with acute leukemia at high bleeding risk: a multicenter study. LEUKEMIA & LYMPHOMA, 1-13-13.