In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
|Numero di pagine||13|
|Rivista||LEUKEMIA & LYMPHOMA|
|Stato di pubblicazione||Published - 2015|
All Science Journal Classification (ASJC) codes
- Cancer Research
Napolitano, M., Casuccio, A., Siragusa, S., Malato, A., Lucchesi, A., Mannina, D., Vetro, C., Candoni, A., Del Principe, M. I., Fabbiano, F., & Di Raimondo, F. (2015). Management of Venous ThromboEmbolism in patients with acute leukemia at high bleeding risk: a multicenter study. LEUKEMIA & LYMPHOMA, 1-13-13.