Management of Toxicity Induced by Anti-EGFR Therapyin Metastatic Colorectal Cancer

Antonio Russo, Giuseppe Bronte, Francesco Passiglia, Marc Peeters, Konstantinos Papadimitriou, Christian Rolfo

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

Use of anti-epidermal growth factor receptor (anti-EGFR) agents has yielded significant advances in the treatment of patients with metastatic colorectal cancer. In fact these drugs, which include the monoclonal antibodies cetuximab and panitumumab, can be delivered both as a single agent and in combination with chemotherapy, achieving better survival and quality of life and in some cases also resectability of metastases. However, these agents can result in the development of toxicities that are usually different from those observed with chemotherapy alone. For the management of these adverse effects, proper knowledge is mandatory. Skin toxicity is the most frequent adverse effect. Other toxicities can be observed, such as hypomagnesemia, gastrointestinal toxicity, and thromboembolic events. Severe infusion reactions can be life-threatening. For these reasons a review of anti-EGFR-drug-related toxicity is useful for clinical practice.
Lingua originaleEnglish
pagine (da-a)250-260
Numero di pagine11
RivistaCurrent Colorectal Cancer Reports
Volume9
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2730???
  • ???subjectarea.asjc.2700.2715???

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