Management of kidney transplantation in a factor VII-deficient patient: case report.

Mariasanta Napolitano, Aloisio, Ferraresi, Famulari, Mirko Pinotti, Mario Lapecorella, Rizza, Clemente, Di Cocco, Alessandro Lucchesi, Francesco Bernardi, Pisani, Mariasanta Napolitano

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine2
RivistaTransplantation Proceedings
Volume44
Stato di pubblicazionePublished - 2012

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Factor VII
Kidney Transplantation
Factor VIIa
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Organ Transplantation
Hemorrhage
Appointments and Schedules
Factor VII Deficiency
Hemorrhagic Disorders
Chronic Kidney Failure
Therapeutics
Transplantation
Safety

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cita questo

Napolitano, M., Aloisio, Ferraresi, Famulari, Pinotti, M., Lapecorella, M., ... Napolitano, M. (2012). Management of kidney transplantation in a factor VII-deficient patient: case report. Transplantation Proceedings, 44, -.

Management of kidney transplantation in a factor VII-deficient patient: case report. / Napolitano, Mariasanta; Aloisio; Ferraresi; Famulari; Pinotti, Mirko; Lapecorella, Mario; Rizza; Clemente; Di Cocco; Lucchesi, Alessandro; Bernardi, Francesco; Pisani; Napolitano, Mariasanta.

In: Transplantation Proceedings, Vol. 44, 2012, pag. -.

Risultato della ricerca: Article

Napolitano, M, Aloisio, Ferraresi, Famulari, Pinotti, M, Lapecorella, M, Rizza, Clemente, Di Cocco, Lucchesi, A, Bernardi, F, Pisani & Napolitano, M 2012, 'Management of kidney transplantation in a factor VII-deficient patient: case report.', Transplantation Proceedings, vol. 44, pagg. -.
Napolitano M, Aloisio, Ferraresi, Famulari, Pinotti M, Lapecorella M e altri. Management of kidney transplantation in a factor VII-deficient patient: case report. Transplantation Proceedings. 2012;44:-.
Napolitano, Mariasanta ; Aloisio ; Ferraresi ; Famulari ; Pinotti, Mirko ; Lapecorella, Mario ; Rizza ; Clemente ; Di Cocco ; Lucchesi, Alessandro ; Bernardi, Francesco ; Pisani ; Napolitano, Mariasanta. / Management of kidney transplantation in a factor VII-deficient patient: case report. In: Transplantation Proceedings. 2012 ; Vol. 44. pagg. -.
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AU - Ferraresi, null

AU - Famulari, null

AU - Pinotti, Mirko

AU - Lapecorella, Mario

AU - Rizza, null

AU - Clemente, null

AU - Di Cocco, null

AU - Lucchesi, Alessandro

AU - Bernardi, Francesco

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AU - Napolitano, Mariasanta

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N2 - Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.

AB - Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.

KW - kidney transplantation, inherited coagulation disorder

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M3 - Article

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JO - Transplantation Proceedings

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