TY - JOUR
T1 - Management of kidney transplantation in a factor VII-deficient patient: case report.
AU - Napolitano, Mariasanta
AU - Lapecorella, Mario
AU - Rizza, null
AU - Clemente, null
AU - Di Cocco, null
AU - Lucchesi, Alessandro
AU - Bernardi, Francesco
AU - Pisani, null
AU - Napolitano, Mariasanta
AU - Napolitano, null
AU - Aloisio, null
AU - Aloisio, null
AU - Ferraresi, null
AU - Famulari, null
AU - Pinotti, Mirko
PY - 2012
Y1 - 2012
N2 - Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.
AB - Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.
KW - inherited coagulation disorder
KW - kidney transplantation
KW - inherited coagulation disorder
KW - kidney transplantation
UR - http://hdl.handle.net/10447/71343
M3 - Article
VL - 44
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
ER -