Management of hepatitis C virus genotype 4: recommendations of an international expert panel.

Pier Luigi Almasio, Massimo Colombo, Stephen A. Harrison, Samuel S. Lee, Nazir Ibrahim, Mahmoud A. Khattab, Stephanos J. Hadziyannis, Ayman A. Abdo, Mohammed Eslam, Nazir Ibrahim, Michael P. Manns, Nazir Ibrahim, Rafael Esteban, Patrice Cacoub, Peter Ferenci

Risultato della ricerca: Articlepeer review

115 Citazioni (Scopus)


HCV has been classified into no fewer than six major genotypes and a series of subtypes. Each HCV genotype is unique with respect to its nucleotide sequence, geographic distribution, and response to therapy. Genotypes 1, 2, and 3 are common throughout North America and Europe. HCV genotype 4 (HCV-4) is common in the Middle East and in Africa, where it is responsible for more than 80% of HCV infections. It has recently spread to several European countries. HCV-4 is considered a major cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma, and liver transplantation in these regions. Although HCV-4 is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in the world, it has not been the subject of widespread research. Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections.
Lingua originaleEnglish
Numero di pagine13
RivistaJournal of Hepatology
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

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