Management of cirrhotic patients with hepatocellular carcinoma treated with sorafenib.

Giuseppe Cabibbo, Emanuela Rolle, Tiziana Pressiani, Francesca Spada, Rodolfo Sacco, Massimo De Giorgio

    Risultato della ricerca: Articlepeer review

    20 Citazioni (Scopus)

    Abstract

    Sorafenib (Nexavar®, Bayer), a multi-targeted tyrosine kinase inhibitor, was the first systemic agent that demonstrated a significant improvement in the overall survival in patients with advanced hepatocellular carcinoma and well-preserved liver function. This drug is now recommended in patients with advanced hepatocellular carcinoma as first-line therapy and for patients not suitable for locoregional treatment. This brief article, produced by a multidisciplinary panel including specialists in gastroenterology and oncology, provides an overview of the major issues related to systemic treatment of hepatocellular carcinoma with sorafenib, including staging and prognostic strategies, assessment of liver disease and its complications, and efficacy and safety of this molecule. Particular emphasis is given on how to improve tolerability of sorafenib in difficult-to-treat patients.
    Lingua originaleEnglish
    pagine (da-a)1807-1816
    Numero di pagine10
    RivistaExpert Review of Anticancer Therapy
    Volume11
    Stato di pubblicazionePublished - 2011

    All Science Journal Classification (ASJC) codes

    • Oncology
    • Pharmacology (medical)

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