Male infertility and mitochondrial DNA

Elena Carra, Elena Carra, Donatella Sangiorgi, Anna Maria Rinaldi, Anna Maria Rinaldi, Francesco Gattuccio

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The mitochondrial machinery plays a key role in the energy production and maintenance of spermatozoa motility. In this paper 200 idiopathic oligo-asthenozoospermic patients were classified on the basis of rapid progressive motility ("a") and sperm concentration. Mitochondrial enzymatic activity was studied and correlated to the viability of sperm cells. Mitochondrial DNA purified from both motile and non-motile sperm of the same individuals was amplificated using PCR. Results suggested that only motile sperm have organelles functional in oxygen consumption, unequivocally demonstrating that motility depends on the mitochondrial activity. Mitochondrial DNA of oligo-asthenozoospermic patients seemed to present some defects that made DNA unavailable for amplification.
Lingua originaleEnglish
pagine (da-a)333-339
Numero di pagine7
RivistaBiochemical and Biophysical Research Communications
Stato di pubblicazionePublished - 2004


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cita questo

Carra, E., Carra, E., Sangiorgi, D., Rinaldi, A. M., Rinaldi, A. M., & Gattuccio, F. (2004). Male infertility and mitochondrial DNA. Biochemical and Biophysical Research Communications, 322, 333-339.