Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Antonina Giammanco, Maurizio Averna, Domenico Di Raimondo, Giuseppe Mule', Antonino Tuttolomondo, Giovanni Cerasola, Mario Barbagallo, Alessandro Scordo, Francesco Antonio Salzano, Giovam Battista Rini, Salvatore Corrao, Andrea Fattorini, Carmelo Butta', Daniele Torres, Francesco Paolo Sposito, Giuseppe Melis, Maria Rosaria Cangemi, Mario Sprovieri, Mauro Anzaldi, Natale Sergio GloriosoVincenzo Zaccone

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.
Lingua originaleEnglish
pagine (da-a)651-660
Numero di pagine10
RivistaInternal and Emergency Medicine
Volume13
Stato di pubblicazionePublished - 2018

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Ankle Brachial Index
Atrial Fibrillation
Chronic Obstructive Pulmonary Disease
Registries
Cause of Death
Blood Vessels
Confidence Intervals
Stroke
Mortality
Cohort Studies
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Emergency Medicine

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Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study. / Giammanco, Antonina; Averna, Maurizio; Di Raimondo, Domenico; Mule', Giuseppe; Tuttolomondo, Antonino; Cerasola, Giovanni; Barbagallo, Mario; Scordo, Alessandro; Salzano, Francesco Antonio; Rini, Giovam Battista; Corrao, Salvatore; Fattorini, Andrea; Butta', Carmelo; Torres, Daniele; Sposito, Francesco Paolo; Melis, Giuseppe; Cangemi, Maria Rosaria; Sprovieri, Mario; Anzaldi, Mauro; Glorioso, Natale Sergio; Zaccone, Vincenzo.

In: Internal and Emergency Medicine, Vol. 13, 2018, pag. 651-660.

Risultato della ricerca: Article

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title = "Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study",
abstract = "Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9{\%}) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95{\%} Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95{\%} CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95{\%} CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.",
author = "Antonina Giammanco and Maurizio Averna and {Di Raimondo}, Domenico and Giuseppe Mule' and Antonino Tuttolomondo and Giovanni Cerasola and Mario Barbagallo and Alessandro Scordo and Salzano, {Francesco Antonio} and Rini, {Giovam Battista} and Salvatore Corrao and Andrea Fattorini and Carmelo Butta' and Daniele Torres and Sposito, {Francesco Paolo} and Giuseppe Melis and Cangemi, {Maria Rosaria} and Mario Sprovieri and Mauro Anzaldi and Glorioso, {Natale Sergio} and Vincenzo Zaccone",
year = "2018",
language = "English",
volume = "13",
pages = "651--660",
journal = "Internal and Emergency Medicine",
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TY - JOUR

T1 - Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

AU - Giammanco, Antonina

AU - Averna, Maurizio

AU - Di Raimondo, Domenico

AU - Mule', Giuseppe

AU - Tuttolomondo, Antonino

AU - Cerasola, Giovanni

AU - Barbagallo, Mario

AU - Scordo, Alessandro

AU - Salzano, Francesco Antonio

AU - Rini, Giovam Battista

AU - Corrao, Salvatore

AU - Fattorini, Andrea

AU - Butta', Carmelo

AU - Torres, Daniele

AU - Sposito, Francesco Paolo

AU - Melis, Giuseppe

AU - Cangemi, Maria Rosaria

AU - Sprovieri, Mario

AU - Anzaldi, Mauro

AU - Glorioso, Natale Sergio

AU - Zaccone, Vincenzo

PY - 2018

Y1 - 2018

N2 - Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.

AB - Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.

UR - http://hdl.handle.net/10447/294974

UR - http://www.springer.com/italy/home?SGWID=6-102-70-173668106-0&changeHeader=true

M3 - Article

VL - 13

SP - 651

EP - 660

JO - Internal and Emergency Medicine

JF - Internal and Emergency Medicine

SN - 1828-0447

ER -