Luminometric Sub-nanoliter Droplet-to-droplet Arrays (LUMDA-chip) for Drug Screening on Phase I Metabolism Enzymes

Giuseppe Domenico Arrabito, Bruno Giuseppe Pignataro, Giuseppe Arrabito, Sabrina Castellano, Clelia Galati

Risultato della ricerca: Articlepeer review

31 Citazioni (Scopus)

Abstract

Here we show the fabrication of the Luminometric Sub-nanoliter Droplet-to-droplet Array (LUMDA chip) byinkjet printing. The chip is easy to be implemented and allows for amultiplexed multi-step biochemical assay insub-nanoliter liquid spots. This concept is here applied to the integral membrane enzyme CYP3A4, i.e. themostrelevant enzymatic target for phase I drug metabolism, and to some structurally-related inhibitors.
Lingua originaleEnglish
pagine (da-a)68-72
Numero di pagine5
RivistaLAB ON A CHIP
Volume13
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1500.1502???
  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1600.1600???
  • ???subjectarea.asjc.2200.2204???

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