Low serum Fetuin A levels and cardiovascular events in End-Stage Renal Disease (ESRD) patients.

Bruna Lo Sasso, Daniela Butera, Antonietta Caruso, Marcello Ciaccio, Chiara Bellia, Giulia Bivona, Rosachiara Carollo, Giulia Bivona, Antonietta Caruso, Rosa C. Carollo, Marcello Ciaccio, Gaia Chiarello, Bruna Lo Sasso, Patrizia Altavilla, Chiara Bellia, Daniela Butera, Gaia Chiarello

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

The atherosclerotic Cardiovascular Disease (CVD) is frequently observed in End-Stage Renal Disease (ESRD) patients; according to the hypothesis of non-traditional risk factors for CVD, accelerated atherogenesis in these patients could be linked to both vascular calcification and inflammation. 2-Heremans-Schmid Glycoprotein (AHSG) also known as Fetuin-A, is considered a negative marker of inflammation and represents one of the in vivo circulating calcification modulators; these molecules are proteins working as endogenous inhibitors of Ca×PO4 precipitation and are probably involved in the pathogenesis vascular calcification. Aim of this study is to evaluate the differences in serum Fetuin-A levels between 2 Haemodialysis (HD) patient groups distinguished on the basis of history of cardio and/or cerebrovascular events. All patients took part in clinical data collection and 2 patient groups were identified as no cardiovascular and cardiovascular on the basis of history of cardio and/or cerebrovascular events. Serum Fetuin-A levels were determined using sandwich immunoenzymatic assay, ELISA (Epitope Diagnostics Inc., San Diego, CA, USA). Serum Fetuin-A levels were significantly lower in cardiovascular HD patients than in those without cardiovascular event. The role of Fetuin A in the context of the different pathogenetic moments of atherosclerosis remains unclearly assessed; it would be of some interest to investigate the hypothesis, almost unexplored, of a relationship between low Fetuin A levels and endothelial dysfunction.
Lingua originaleEnglish
pagine (da-a)200-202
Numero di pagine3
RivistaResearch Journal of Medical Sciences
Volume2
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

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