Low Rate of Oral Human Papillomavirus (HPV) Infection in Women Screened for Cervical HPV Infection in Southern Italy: A Cross-Sectional Study of 140 Immunocompetent Subjects

Termine, N.; Giovannelli, L.; Panzarella, V.; D'Angelo, M.

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25 Citazioni (Scopus)

Abstract

Even though the natural history of cervical and oral human papillomavirus (HPV) infection has been investigated intensely, the possibility that HPV may infect both sites in the same subject is not well documented. This study investigated the frequency of concurrent oral and cervical HPV infection in southern Italian women, in the light of some selected socio-behavioral variables. One hundred forty women (mean age: 36 years), with known cervical HPV status, were analyzed for oral HPV. Age, smoking/drinking habits, clinical and socio-behavioral history were assessed by personal interviews. Oral mucosal cells were collected by oral brushing and HPV DNA was sought by the use of nested PCR amplification followed by direct DNA sequencing and the commercial assay INNOLiPA HPV Genotyping (Innogenetics N.V., Ghent, Belgium). The data were analyzed by using the chi-square test and a logistic regression (logit) model (P < 0.05 statistically significant). Oral HPV infection was detected in 2/140 (1.4%) cases, being present in 2/76 (2.6%) women with cervical HPV infection and 0/64 uninfected women (P = 0.19). A lack of type-specific concordance in the two patients with concurrent infection was observed. In the sample of population examined, HPV cervical infection does not seem to predispose to oral transmission, even in the presence of oral-genital sexual habits, thus suggesting the independence of infection at the two mucosal sites
Lingua originaleEnglish
pagine (da-a)1438-1443
Numero di pagine6
RivistaJournal of Medical Virology
Volume2009
Stato di pubblicazionePublished - 2009

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Papillomavirus Infections
Italy
Habits
Logistic Models
Belgium
Chi-Square Distribution
Infection
Natural History
DNA Sequence Analysis
Drinking
Smoking
History
Interviews
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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title = "Low Rate of Oral Human Papillomavirus (HPV) Infection in Women Screened for Cervical HPV Infection in Southern Italy: A Cross-Sectional Study of 140 Immunocompetent Subjects",
abstract = "Even though the natural history of cervical and oral human papillomavirus (HPV) infection has been investigated intensely, the possibility that HPV may infect both sites in the same subject is not well documented. This study investigated the frequency of concurrent oral and cervical HPV infection in southern Italian women, in the light of some selected socio-behavioral variables. One hundred forty women (mean age: 36 years), with known cervical HPV status, were analyzed for oral HPV. Age, smoking/drinking habits, clinical and socio-behavioral history were assessed by personal interviews. Oral mucosal cells were collected by oral brushing and HPV DNA was sought by the use of nested PCR amplification followed by direct DNA sequencing and the commercial assay INNOLiPA HPV Genotyping (Innogenetics N.V., Ghent, Belgium). The data were analyzed by using the chi-square test and a logistic regression (logit) model (P < 0.05 statistically significant). Oral HPV infection was detected in 2/140 (1.4{\%}) cases, being present in 2/76 (2.6{\%}) women with cervical HPV infection and 0/64 uninfected women (P = 0.19). A lack of type-specific concordance in the two patients with concurrent infection was observed. In the sample of population examined, HPV cervical infection does not seem to predispose to oral transmission, even in the presence of oral-genital sexual habits, thus suggesting the independence of infection at the two mucosal sites",
keywords = "HPV infection; oral mucosa; cervical mucosa; oral–genital infection; sexually transmitted infection (STI)",
author = "{Termine, N.; Giovannelli, L.; Panzarella, V.; D'Angelo, M.} and Pietro Ammatuna and Antonino Perino and Giuseppina Campisi and Domenica Matranga",
year = "2009",
language = "English",
volume = "2009",
pages = "1438--1443",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",

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T1 - Low Rate of Oral Human Papillomavirus (HPV) Infection in Women Screened for Cervical HPV Infection in Southern Italy: A Cross-Sectional Study of 140 Immunocompetent Subjects

AU - Termine, N.; Giovannelli, L.; Panzarella, V.; D'Angelo, M.

AU - Ammatuna, Pietro

AU - Perino, Antonino

AU - Campisi, Giuseppina

AU - Matranga, Domenica

PY - 2009

Y1 - 2009

N2 - Even though the natural history of cervical and oral human papillomavirus (HPV) infection has been investigated intensely, the possibility that HPV may infect both sites in the same subject is not well documented. This study investigated the frequency of concurrent oral and cervical HPV infection in southern Italian women, in the light of some selected socio-behavioral variables. One hundred forty women (mean age: 36 years), with known cervical HPV status, were analyzed for oral HPV. Age, smoking/drinking habits, clinical and socio-behavioral history were assessed by personal interviews. Oral mucosal cells were collected by oral brushing and HPV DNA was sought by the use of nested PCR amplification followed by direct DNA sequencing and the commercial assay INNOLiPA HPV Genotyping (Innogenetics N.V., Ghent, Belgium). The data were analyzed by using the chi-square test and a logistic regression (logit) model (P < 0.05 statistically significant). Oral HPV infection was detected in 2/140 (1.4%) cases, being present in 2/76 (2.6%) women with cervical HPV infection and 0/64 uninfected women (P = 0.19). A lack of type-specific concordance in the two patients with concurrent infection was observed. In the sample of population examined, HPV cervical infection does not seem to predispose to oral transmission, even in the presence of oral-genital sexual habits, thus suggesting the independence of infection at the two mucosal sites

AB - Even though the natural history of cervical and oral human papillomavirus (HPV) infection has been investigated intensely, the possibility that HPV may infect both sites in the same subject is not well documented. This study investigated the frequency of concurrent oral and cervical HPV infection in southern Italian women, in the light of some selected socio-behavioral variables. One hundred forty women (mean age: 36 years), with known cervical HPV status, were analyzed for oral HPV. Age, smoking/drinking habits, clinical and socio-behavioral history were assessed by personal interviews. Oral mucosal cells were collected by oral brushing and HPV DNA was sought by the use of nested PCR amplification followed by direct DNA sequencing and the commercial assay INNOLiPA HPV Genotyping (Innogenetics N.V., Ghent, Belgium). The data were analyzed by using the chi-square test and a logistic regression (logit) model (P < 0.05 statistically significant). Oral HPV infection was detected in 2/140 (1.4%) cases, being present in 2/76 (2.6%) women with cervical HPV infection and 0/64 uninfected women (P = 0.19). A lack of type-specific concordance in the two patients with concurrent infection was observed. In the sample of population examined, HPV cervical infection does not seem to predispose to oral transmission, even in the presence of oral-genital sexual habits, thus suggesting the independence of infection at the two mucosal sites

KW - HPV infection; oral mucosa; cervical mucosa; oral–genital infection; sexually transmitted infection (STI)

UR - http://hdl.handle.net/10447/42129

M3 - Article

VL - 2009

SP - 1438

EP - 1443

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

ER -