Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Mario Giuseppe Mirisola, Brian K. Kennedy, Min Wei, Chia-Wei Cheng, Sebastian Brandhorst, Junxiang Wan, Jorge A. Suarez, Federica Madia, Pinchas Cohen, Priya Balasubramanian, Luigi Fontana, Mario G. Mirisola, Jaime Guevara-Aguirre, Eileen M. Crimmins, Giuseppe Passarino, Valter D. Longo, Morgan E. Levine

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316 Citazioni (Scopus)

Abstract

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.
Lingua originaleEnglish
pagine (da-a)407-417
Numero di pagine11
RivistaCell Metabolism
Volume3
Stato di pubblicazionePublished - 2014

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cita questo

Mirisola, M. G., Kennedy, B. K., Wei, M., Cheng, C-W., Brandhorst, S., Wan, J., Suarez, J. A., Madia, F., Cohen, P., Balasubramanian, P., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Crimmins, E. M., Passarino, G., Longo, V. D., & Levine, M. E. (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism, 3, 407-417.