Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials

Vincenza Tarantino, Vincenza Tarantino, Demis Basso, Giorgio Arcara, John C. Rothwell, Elias P. Casula, Giuliana Marino, Patrizia S. Bisiacchi, Gianna Maria Toffolo

Risultato della ricerca: Article

48 Citazioni (Scopus)

Abstract

The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs).We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M1-rTMS resulted in a significant decrease of MEP amplitude and in a significant increase of P60 and N100 amplitude. There was no effect after V1-rTMS.1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials. Our results confirm the reliability of the TMS-evoked N100 as a marker of cortical inhibition and provide insight into the neuromodulatory effects of 1-Hz rTMS. The present finding could be of relevance for therapeutic and diagnostic purposes. © 2014 Elsevier Inc.
Lingua originaleEnglish
pagine (da-a)225-232
Numero di pagine8
RivistaNeuroImage
Volume98
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

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    Tarantino, V., Tarantino, V., Basso, D., Arcara, G., Rothwell, J. C., Casula, E. P., Marino, G., Bisiacchi, P. S., & Toffolo, G. M. (2014). Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials. NeuroImage, 98, 225-232.