TY - JOUR
T1 - Low-Dose Aspirin Use and Cognitive Function in Older Age: A Systematic Review and Meta-analysis
AU - Veronese, Nicola
AU - Schofield, Patricia
AU - Thompson, Trevor
AU - Veronese, Nicola
AU - Tseng, Ping-Tao
AU - Carvalho, André F.
AU - Muller, Christoph
AU - Thompson, Trevor
AU - Maggi, Stefania
AU - Stubbs, Brendon
AU - Solmi, Marco
AU - Lin, Pao-Yen
PY - 2017
Y1 - 2017
N2 - Objectives: To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia. Design: Systematic review and meta-analysis. Setting: Observational and interventional studies. Participants: Individuals with no dementia or cognitive impairment initially. Measurements: Odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for the maximum number of covariates from each study, were used to summarize data on the incidence of dementia and cognitive impairment in observational studies. Standardized mean differences (SMDs) were used for cognitive test scores in RCTs. Results: Of 2,341 potentially eligible articles, eight studies were included and provided data for 36,196 participants without dementia or cognitive impairment at baseline (mean age 66, 63% female). After adjusting for a median of three potential confounders over a median follow-up period of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment (5 studies, N = 26,159; OR = 0.82, 95% CI = 0.55–1.22, P =.33, I2 = 67%). In three RCTs (N = 10,037; median follow-up 5 years), the use of low-dose aspirin was not associated with significantly better global cognition (SMD=0.005, 95% CI=–0.04–0.05, P =.84, I2 = 0%) in individuals without dementia. Adherence was lower in participants taking aspirin than in controls, and the incidence of adverse events was higher. Conclusion: This review found no evidence that low-dose aspirin buffers against cognitive decline or dementia or improves cognitive test scores in RCTs. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society
AB - Objectives: To investigate whether low-dose aspirin (<300 mg/d) can influence the onset of cognitive impairment or dementia in observational studies and improve cognitive test scores in randomized controlled trials (RCTs) in participants without dementia. Design: Systematic review and meta-analysis. Setting: Observational and interventional studies. Participants: Individuals with no dementia or cognitive impairment initially. Measurements: Odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for the maximum number of covariates from each study, were used to summarize data on the incidence of dementia and cognitive impairment in observational studies. Standardized mean differences (SMDs) were used for cognitive test scores in RCTs. Results: Of 2,341 potentially eligible articles, eight studies were included and provided data for 36,196 participants without dementia or cognitive impairment at baseline (mean age 66, 63% female). After adjusting for a median of three potential confounders over a median follow-up period of 6 years, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment (5 studies, N = 26,159; OR = 0.82, 95% CI = 0.55–1.22, P =.33, I2 = 67%). In three RCTs (N = 10,037; median follow-up 5 years), the use of low-dose aspirin was not associated with significantly better global cognition (SMD=0.005, 95% CI=–0.04–0.05, P =.84, I2 = 0%) in individuals without dementia. Adherence was lower in participants taking aspirin than in controls, and the incidence of adverse events was higher. Conclusion: This review found no evidence that low-dose aspirin buffers against cognitive decline or dementia or improves cognitive test scores in RCTs. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society
UR - http://hdl.handle.net/10447/456221
M3 - Article
VL - 65
SP - 1763
EP - 1768
JO - JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
JF - JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
SN - 1532-5415
ER -