Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis

Angelo Ferrante, Giuseppe Licata, Giovanni Triolo, Francesco Ciccia, Gino Avellone, Gaspare Parrinello, Annarita Giardina, Giuseppe Licata, Impastato, Avellone, Giovanni Triolo, Francesco Ciccia, Anna Rita Giardina, Parrinello, Giardina, Angelo Ferrante, Rosalia Impastato

Risultato della ricerca: Articlepeer review

31 Citazioni (Scopus)

Abstract

The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant variation of ca-IMT was observed after 2 years in MTX-treated patients. Our study indicates that anti-TNF blocking agents, but not methotrexate, are capable of reducing IMT of carotid arteries in female RA patients in a 2-year follow-up.
Lingua originaleEnglish
pagine (da-a)193-198
Numero di pagine6
RivistaRheumatology International
Volume30
Stato di pubblicazionePublished - 2009

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2745???
  • ???subjectarea.asjc.2400.2403???

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