Liver stiffness quantification in patients with non-alcoholic steatohepatitis: comparison of shear wave elastography and transient elastography with liver biopsy correlation

Salvatore Petta, Vito Di Marco, Tommaso Vincenzo Bartolotta, Adele Taibbi, Roberto Cannella, Dario Giambelluca, Gabriele Buse', Giovanni Caruana, Giuseppe Cutaia

Risultato della ricerca: Other


Purpose: To assess the accuracy of liver stiffness quantification in patientswith non-alcoholic steatohepatitis (NASH) using shear wave elastography(SWE) in comparison with transient elastography (TE).Methods and Materials: This is a prospective study performed in a singleinstitution, including 49 patients with histological diagnosis of NASH. Thestiffness of the right liver lobe was measured on the same day with twotechniques: TE (FibroScan, Echosens), and SWE (RS80A ultrasound system,Samsung Medison). In the SWE evaluation, 11 patients were excluded due tomore than 75% measurements fails. Receiver operating curves (ROC), areasunder the ROC (AUROC) and 95% confidence intervals (CI) were calculated toassess the accuracy of TE and SWE for the diagnosis of significant fibrosis(F2-F4) and advanced fibrosis (F3-F4). Spearman’s rank coefficient (rho) wasused for correlation of TE with SWE. A p<0.05 was considered for statisticalsignificance.Results: 38 patients were included in the final population. Overall 24 (63%)patients had significant fibrosis and 17 (45%) had advanced fibrosis. TE andSWE showed an AUROC of 0.711 (95% CI: 0.545-0.877, p=0.032) and 0.729(95% CI: 0.562-0.896, p=0.020) for the diagnosis of significant fibrosis. TheAUROC for the diagnosis of advanced fibrosis were 0.803 (95% CI: 0.648-0.9580, p=0.002) and 0.811 (95% CI: 0.667-0.955, p=0.001) for TE and SWE,respectively. There was a significant correlation between TE and SWEmeasurements (rho=0.455, p = 0.004).Conclusion: SWE and TE have both a good accuracy, with a significantcorrelation, for the diagnosis of advanced fibrosis in NASH-patients.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2019


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