Liver stiffness quantification in biopsy-proven nonalcoholic fatty liver disease patients using shear wave elastography in comparison with transient elastography

Tommaso Vincenzo Bartolotta, Massimo Midiri, Adele Taibbi, Salvatore Petta, Domenica Matranga, Roberto Cannella, Adele Taibbi, Giovanni Caruana, Roberto Cannella, Gabriele Busè, Tommaso Vincenzo Bartolotta, Massimo Midiri

Risultato della ricerca: Articlepeer review

Abstract

Purpose: This study prospectively assessed the performance of liver stiffness measurementsusing point shear-wave elastography (p-SWE) in comparison with transient elastography (TE) inpatients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).Methods: Fifty-six consecutive adult patients with a histological diagnosis of NAFLD prospectivelyunderwent TE and p-SWE on the same day. The median of 10 measurements (SWE-10), the firstfive (SWE-5), and the first three (SWE-3) measurements were analyzed for p-SWE. Liver biopsywas considered as the reference standard for liver fibrosis grade. Receiver operating characteristic(ROC) curves and areas under the ROC curves (AUROCs) were calculated to assess the performanceof TE and p-SWE for the diagnosis of significant (F2-F4) and advanced fibrosis (F3-F4).Results: Forty-six patients (27 men, 19 women; mean age, 54.7±9.1 years) had valid p-SWE andTE measurements. Twenty-seven patients (58.7%) had significant fibrosis and 18 (39.1%) hadadvanced fibrosis. For significant fibrosis, both SWE-10 (AUROC, 0.787; P=0.002) and SWE-5 (AUROC, 0.809; P=0.001) provided higher diagnostic performance than TE (AUROC, 0.719;P=0.016) and SWE-3 (AUROC, 0.714; P=0.021), albeit without statistical significance (P=0.301).For advanced fibrosis, SWE-5 showed higher diagnostic performance (AUROC, 0.809; P<0.001)than TE (AUROC, 0.799; P<0.001), SWE-10 (AUROC, 0.797; P<0.001), and SWE-3 (AUROC,0.736; P=0.003), although the differences were not statistically significant (P=0.496). Theoptimal SWE-10 and SWE-5 cutoff values were ≥8.4 and ≥7.8 for significant fibrosis, and ≥9.1and ≥8.8 for advanced fibrosis, respectively.Conclusion: TE and p-SWE showed similar performance for the diagnosis of significant andadvanced fibrosis in NAFLD patients.
Lingua originaleEnglish
pagine (da-a)407-416
Numero di pagine10
RivistaUltrasonography
Volume40
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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