Abstract

Lipids are used by the liver mainly for energy storage and membranebuilding, but they also contribute to cell signaling. Fattyliver is characterized by activation of metabolic and inflammatorypathways. In this work differences in lipidomic profiles of sphyngolipids(SL) and fatty acids (FA) have been evaluated in biopsiesfrom 10 NAFLD patients, 22 (14 FL, 8 w/o FL) HCV patients and13 healthy controls.FL is characterized by increased content of the main FA as myristic,palmitic, oleic, linoleic, saturated and monounsaturated FA inboth model. FL of HCV is characterized by a more severe degreeof cell damage and fibrosis associated with an increase of palmitoleicacid, long chain SL and desaturase (SCD) activity, measuredas oleic/stearic ratio.FL of NAFLD shows a higher degree of metabolic disturbances asincreased total cholesterol, triglycerides, HOMA, some long chainFA (C21:0, C22:2, C24:1) and n9 FA. A combination of 6 FA and 4SL completely resolved the two model of FL (NAFLD, HCV) fromnon-FL by discriminant analysis. HCV vs healthy non-FL patientsshowed higher levels of long chain SL.In conclusion FL is characterized by accumulation of the mostabundant FA, but only FL of HCV is characterized by increasedlong chain SL. The accumulation of SL, in particular ceramides,might be responsible of the more severe features of FL due to HCVinfection.
Lingua originaleEnglish
Pagine73-73
Numero di pagine1
Stato di pubblicazionePublished - 2011

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