Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells

Chiara Botto, Emanuela Fabiola Craparo, Erika Amore, Maria Luisa Bondì, Melchiorre Cervello, Giuseppa Augello, Maria Rita Emma

Risultato della ricerca: Articlepeer review

21 Citazioni (Scopus)

Abstract

Here, the potential of two nanostructured lipid carriers (NLC) for controlled release of sorafenib was evaluated. The obtained systems showed characteristics suitable as drug delivery systems for the treatment of hepatocellular carcinoma (HCC) through parenteral administration. The use of a mixture between a solid lipid (tripalmitin) with a liquid lipid (Captex 355 EP/NF or Miglyol 812) to prepare NLC systems could give a higher drug loading capacity and a longer term stability during storage than that obtained by using only solid lipids. The obtained nanoparticles showed a nanometer size and high negative zeta potential values. Scansion electron microscopy (SEM) of the sorafenib loaded NLC revealed a spherical shape with a diameter <300 nm. In vitro biological studies demonstrated that sorafenib loaded into NLC had enhanced anti-tumor activity compared to that of free drug. This finding raises hope in terms of future drug delivery strategy of sorafenib loaded NLC, that can be useful for therapeutic application in HCC.
Lingua originaleEnglish
pagine (da-a)75-85
Numero di pagine11
RivistaInternational Journal of Pharmaceutics
Volume493
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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