LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement

Federica Vernuccio, Federica Vernuccio, Alessandro Furlan, Mathias Meyer, Rajan T. Gupta, Mustafa R. Bashir, Fides R. Schwartz, Roberto Cannella, Fides R. Schwartz, Kingshuk Roy Choudhoury, Fernando Gonzáles, Daniele Marin, Roberto Cannella

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.
Lingua originaleEnglish
pagine (da-a)W57-W65
Numero di pagine9
RivistaAmerican Journal of Roentgenology
Volume213
Stato di pubblicazionePublished - 2019

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Information Systems
Hepatocellular Carcinoma
Liver
Logistic Models
Capsules
Sensitivity and Specificity
Growth

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. / Vernuccio, Federica; Vernuccio, Federica; Furlan, Alessandro; Meyer, Mathias; Gupta, Rajan T.; Bashir, Mustafa R.; Schwartz, Fides R.; Cannella, Roberto; Schwartz, Fides R.; Choudhoury, Kingshuk Roy; Gonzáles, Fernando; Marin, Daniele; Cannella, Roberto.

In: American Journal of Roentgenology, Vol. 213, 2019, pag. W57-W65.

Risultato della ricerca: Article

Vernuccio, F, Vernuccio, F, Furlan, A, Meyer, M, Gupta, RT, Bashir, MR, Schwartz, FR, Cannella, R, Schwartz, FR, Choudhoury, KR, Gonzáles, F, Marin, D & Cannella, R 2019, 'LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement', American Journal of Roentgenology, vol. 213, pagg. W57-W65.
Vernuccio, Federica ; Vernuccio, Federica ; Furlan, Alessandro ; Meyer, Mathias ; Gupta, Rajan T. ; Bashir, Mustafa R. ; Schwartz, Fides R. ; Cannella, Roberto ; Schwartz, Fides R. ; Choudhoury, Kingshuk Roy ; Gonzáles, Fernando ; Marin, Daniele ; Cannella, Roberto. / LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement. In: American Journal of Roentgenology. 2019 ; Vol. 213. pagg. W57-W65.
@article{64c2b5a27c574c47a70f41612cd1b9bd,
title = "LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement",
abstract = "OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84{\%} [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84{\%} [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73{\%} [44/60]) and specificity (85{\%}, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95{\%} (76/80) for washout, 100{\%} (80/80) for enhancing capsule, and 99{\%} (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.",
author = "Federica Vernuccio and Federica Vernuccio and Alessandro Furlan and Mathias Meyer and Gupta, {Rajan T.} and Bashir, {Mustafa R.} and Schwartz, {Fides R.} and Roberto Cannella and Schwartz, {Fides R.} and Choudhoury, {Kingshuk Roy} and Fernando Gonz{\'a}les and Daniele Marin and Roberto Cannella",
year = "2019",
language = "English",
volume = "213",
pages = "W57--W65",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",

}

TY - JOUR

T1 - LI-RADS: Diagnostic Performance of Hepatobiliary Phase Hypointensity and Major Imaging Features of LR-3 and LR-4 Lesions Measuring 10-19 mm With Arterial Phase Hyperenhancement

AU - Vernuccio, Federica

AU - Vernuccio, Federica

AU - Furlan, Alessandro

AU - Meyer, Mathias

AU - Gupta, Rajan T.

AU - Bashir, Mustafa R.

AU - Schwartz, Fides R.

AU - Cannella, Roberto

AU - Schwartz, Fides R.

AU - Choudhoury, Kingshuk Roy

AU - Gonzáles, Fernando

AU - Marin, Daniele

AU - Cannella, Roberto

PY - 2019

Y1 - 2019

N2 - OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.

AB - OBJECTIVE. The purpose of this study was to determine the diagnostic performance of hepatobiliary phase hypointensity and Liver Imaging Reporting and Data System (LI-RADS) major imaging features in the diagnosis of hepatocellular carcinoma (HCC) in hepatic lesions with arterial phase hyperenhancement (APHE) measuring 10-19 mm in patients at high risk of HCC. MATERIALS AND METHODS. A composite reference standard of pathologic analysis and imaging follow-up was used. The diagnostic performance (sensitivity and specificity) of hepatobiliary phase hypointensity and LI-RADS major imaging features other than APHE for the diagnosis of HCC was assessed and compared by means of a logistic regression model. RESULTS. This retrospective dual-institution study included 189 LI-RADS LR-3 and LR-4 lesions measuring 10-19 mm and having APHE in 144 consecutively registered patients (96 men, 48 women; mean age, 58 years). Hepatobiliary phase hypointensity had significantly higher sensitivity (84% [92/109], p < 0.00001) than major imaging features in the diagnosis of HCC but lower specificity (84% [67/80]; p = 0.01). However, hepatobiliary phase hypointensity in LR-3 observations measuring 10-19 mm and having APHE had moderately elevated sensitivity (73% [44/60]) and specificity (85%, 64/75). All three major imaging features had high specificity for the diagnosis of HCC, including 95% (76/80) for washout, 100% (80/80) for enhancing capsule, and 99% (79/80) for threshold growth. CONCLUSION. Major imaging features have high specificity for the diagnosis of HCC in lesions measuring 10-19 mm that have APHE. The finding of hepatobiliary phase hypointensity significantly improves sensitivity while moderately high specificity is maintained for the diagnosis of HCC in LR-3 lesions measuring 10-19 mm that exhibit APHE.

UR - http://hdl.handle.net/10447/366848

M3 - Article

VL - 213

SP - W57-W65

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

ER -