Levetiracetam in Neonatal Seizures as First-line Treatment: A Prospective Study

Giovanni Corsello, Giovanna Vitaliti, Nassim Matin, Nazgol Motamed-Gorji, Catia Romano, Piero Pavone, Laura Mauceri, Raffaele Falsaperla, Riccardo Lubrano, Piero Pavone, Raffaele Falsaperla

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

AIM OF THE STUDY:The aim of this study is to evaluate the efficacy and safety of levetiracetam (LEV) as first-line treatment of neonatal seizures.MATERIALS AND METHODS:This study was conducted in patients of Neonatal Intensive Care Unit of Santo Bambino Hospital, University of Catania, Italy, from January to August 2016. A total of 16 neonates with convulsions not associated with major syndromes, which required anticonvulsant therapy, were included and underwent IV LEV at standard doses.RESULTS:All patients responded to treatment, with a variety range of seizure resolution period (from 24 h to 15 days; mean hours: 96 ± 110.95). No patient required a second anticonvulsant therapy. Regarding safety of LEV, no major side-effects were observed.CONCLUSIONS:To our knowledge, it is one of the few studies confirming the efficiency of LEV as first-line treatment in seizures of this age group. LEV was effective in resolving seizures and was safely administered in the current study.
Lingua originaleEnglish
pagine (da-a)24-28
Numero di pagine5
RivistaJournal of Pediatric Neurosciences
Volume12
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
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