Abstract
Background: Neutropenia and its complicationsrepresent one of the principal dose-limiting toxicity issues inchemotherapeutic regimens for soft tissue sarcoma.Prophylactic granulocyte colony-stimulating factor (G-CSF)reduces the risk of febrile neutropenia (FN). The correcttiming of G-CSF administration should be considered in orderto optimize the prophylactic treatment. Patients and Methods:Patients (≥18 years old) affected by soft tissue sarcoma andtreated with epirubicin and ifosfamide, underwent prophylactictreatment with G-CSF (lenograstim at 263 μg) from day 5 today 9. The proportion of patients experiencing FN and G4neutropenia was considered. Results: A total of 36 patientsreceiving three cycles of chemotherapy with epirubicin plusifosfamide were treated. None developed FN; G4 neutropeniawas reported in 17% of patients. No treatment delay or dosereduction was required, no antibiotic therapy wasadministered and no hospitalization occurred. Conclusion:Five-day lenograstim treatment is efficient as prophylaxis ofFN for soft tissue sarcoma chemotherapy regimens and allowsmaintenance of chemotherapy dose intensity.
Lingua originale | English |
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pagine (da-a) | 679-684 |
Numero di pagine | 6 |
Rivista | Anticancer Research |
Volume | 33 |
Stato di pubblicazione | Published - 2013 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research