L’efficacia del trinitrato di glicerina allo 0,2% per uso topico nel ridurre il dolore post- emorroidectomia e favorire la guarigione delle ferite

Salvatore Buscemi, Sebastiano Bonventre, Matteo Arcara, Gaetano Giuseppe Di Vita, Maria Grazia Angileri, Rosalia Patti, Rosaria Salerno

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Abstract

The aim of the study was to evaluate whether topical application of 0.2% glyceryl trinitrate ointment could reduce post-haemorrhoidectomy healing time and pain both at rest and during defecation. Thirty patients with grade III and IV haemorrhoids were included in the study and divided into two groups. All patients underwent Milligan-Morgan haemorrhoidectomy, and anorectal manometry was performed before surgery and after 5 and 30 days. In one group a placebo ointment was applied to the perianal wounds, while in the other group a 0.2% glyceryl trinitrate ointment was used. Maximum resting pressure was reduced in the glyceryl trinitrate group and increased in the placebo group after 5 days. Postoperative pain both at rest and during defecation, and the time to healing and return to normal activity were significantly reduced in the glyceryl trinitrate group, whilst analgesic consumption was similar. An elevated incidence of headache was observed In the glyceryl trinitrate group. Topical application of glyceryl trinitrate was effective in reducing postoperative pain and healing time, but the substantial incidence of side effects may limit its extensive use.
Lingua originaleItalian
pagine (da-a)77-85
Numero di pagine9
RivistaChirurgia Italiana
Volume57
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Surgery

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title = "L’efficacia del trinitrato di glicerina allo 0,2{\%} per uso topico nel ridurre il dolore post- emorroidectomia e favorire la guarigione delle ferite",
abstract = "The aim of the study was to evaluate whether topical application of 0.2{\%} glyceryl trinitrate ointment could reduce post-haemorrhoidectomy healing time and pain both at rest and during defecation. Thirty patients with grade III and IV haemorrhoids were included in the study and divided into two groups. All patients underwent Milligan-Morgan haemorrhoidectomy, and anorectal manometry was performed before surgery and after 5 and 30 days. In one group a placebo ointment was applied to the perianal wounds, while in the other group a 0.2{\%} glyceryl trinitrate ointment was used. Maximum resting pressure was reduced in the glyceryl trinitrate group and increased in the placebo group after 5 days. Postoperative pain both at rest and during defecation, and the time to healing and return to normal activity were significantly reduced in the glyceryl trinitrate group, whilst analgesic consumption was similar. An elevated incidence of headache was observed In the glyceryl trinitrate group. Topical application of glyceryl trinitrate was effective in reducing postoperative pain and healing time, but the substantial incidence of side effects may limit its extensive use.",
keywords = "Haemorrhoidectomy, glyceryl trinitrate, post-haemorrhoidectomy pain",
author = "Salvatore Buscemi and Sebastiano Bonventre and Matteo Arcara and {Di Vita}, {Gaetano Giuseppe} and Angileri, {Maria Grazia} and Rosalia Patti and Rosaria Salerno",
year = "2005",
language = "Italian",
volume = "57",
pages = "77--85",
journal = "Updates in Surgery",
issn = "2038-131X",
publisher = "Springer-Verlag Italia",

}

TY - JOUR

T1 - L’efficacia del trinitrato di glicerina allo 0,2% per uso topico nel ridurre il dolore post- emorroidectomia e favorire la guarigione delle ferite

AU - Buscemi, Salvatore

AU - Bonventre, Sebastiano

AU - Arcara, Matteo

AU - Di Vita, Gaetano Giuseppe

AU - Angileri, Maria Grazia

AU - Patti, Rosalia

AU - Salerno, Rosaria

PY - 2005

Y1 - 2005

N2 - The aim of the study was to evaluate whether topical application of 0.2% glyceryl trinitrate ointment could reduce post-haemorrhoidectomy healing time and pain both at rest and during defecation. Thirty patients with grade III and IV haemorrhoids were included in the study and divided into two groups. All patients underwent Milligan-Morgan haemorrhoidectomy, and anorectal manometry was performed before surgery and after 5 and 30 days. In one group a placebo ointment was applied to the perianal wounds, while in the other group a 0.2% glyceryl trinitrate ointment was used. Maximum resting pressure was reduced in the glyceryl trinitrate group and increased in the placebo group after 5 days. Postoperative pain both at rest and during defecation, and the time to healing and return to normal activity were significantly reduced in the glyceryl trinitrate group, whilst analgesic consumption was similar. An elevated incidence of headache was observed In the glyceryl trinitrate group. Topical application of glyceryl trinitrate was effective in reducing postoperative pain and healing time, but the substantial incidence of side effects may limit its extensive use.

AB - The aim of the study was to evaluate whether topical application of 0.2% glyceryl trinitrate ointment could reduce post-haemorrhoidectomy healing time and pain both at rest and during defecation. Thirty patients with grade III and IV haemorrhoids were included in the study and divided into two groups. All patients underwent Milligan-Morgan haemorrhoidectomy, and anorectal manometry was performed before surgery and after 5 and 30 days. In one group a placebo ointment was applied to the perianal wounds, while in the other group a 0.2% glyceryl trinitrate ointment was used. Maximum resting pressure was reduced in the glyceryl trinitrate group and increased in the placebo group after 5 days. Postoperative pain both at rest and during defecation, and the time to healing and return to normal activity were significantly reduced in the glyceryl trinitrate group, whilst analgesic consumption was similar. An elevated incidence of headache was observed In the glyceryl trinitrate group. Topical application of glyceryl trinitrate was effective in reducing postoperative pain and healing time, but the substantial incidence of side effects may limit its extensive use.

KW - Haemorrhoidectomy

KW - glyceryl trinitrate

KW - post-haemorrhoidectomy pain

UR - http://hdl.handle.net/10447/13052

M3 - Article

VL - 57

SP - 77

EP - 85

JO - Updates in Surgery

JF - Updates in Surgery

SN - 2038-131X

ER -