Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 1613-1620 |
| Numero di pagine | 8 |
| Rivista | British Journal of Dermatology |
| Volume | 172 |
| Stato di pubblicazione | Published - 2015 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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Latent tuberculosis infection in patients with chronic plaque psoriasis: Evidence from the Italian Psocare Registry. / Baglieri, Francesco; Anastasio, Francesca; Bongiorno, Maria Rita; Mirulla, Agostino Igor; Giannetti, Aurora; Guarneri, Bina Claudia; Di Dio, Cinzia; Di Vito, Concetta; Condello, Gaia Elena Maria; Cannata, Giuseppe; Monfrecola, Giuseppe; Di Mattei, Ida; Prezzemolo, Livia Maria Caterina; Zappala', Loredana; De Angelis, Lucilla; Lo Forte, Maria Rita; Angileri, Rosa Giuseppa; Murgia, Selene; La Greca, Sigfrido Giuseppe.
In: British Journal of Dermatology, Vol. 172, 2015, pag. 1613-1620.Risultato della ricerca: Article
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TY - JOUR
T1 - Latent tuberculosis infection in patients with chronic plaque psoriasis: Evidence from the Italian Psocare Registry
AU - Baglieri, Francesco
AU - Anastasio, Francesca
AU - Bongiorno, Maria Rita
AU - Mirulla, Agostino Igor
AU - Giannetti, Aurora
AU - Guarneri, Bina Claudia
AU - Di Dio, Cinzia
AU - Di Vito, Concetta
AU - Condello, Gaia Elena Maria
AU - Cannata, Giuseppe
AU - Monfrecola, Giuseppe
AU - Di Mattei, Ida
AU - Prezzemolo, Livia Maria Caterina
AU - Zappala', Loredana
AU - De Angelis, Lucilla
AU - Lo Forte, Maria Rita
AU - Angileri, Rosa Giuseppa
AU - Murgia, Selene
AU - La Greca, Sigfrido Giuseppe
PY - 2015
Y1 - 2015
N2 - Background The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8.3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4.3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen-ultraviolet A (P < 0.05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1.30, 95% confidence interval (CI) 1.04-1.62; P = 0.02], age over 55 years (OR 2.93, 95% CI 2.18-3.93; P < 0.001) and being entered into a conventional treatment (OR 3.83, 95% CI 3.10-4.74; P < 0.001). Positive history of tuberculosis was seen in 1% of patients (n = 49). Conclusions The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.
AB - Background The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8.3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4.3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen-ultraviolet A (P < 0.05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1.30, 95% confidence interval (CI) 1.04-1.62; P = 0.02], age over 55 years (OR 2.93, 95% CI 2.18-3.93; P < 0.001) and being entered into a conventional treatment (OR 3.83, 95% CI 3.10-4.74; P < 0.001). Positive history of tuberculosis was seen in 1% of patients (n = 49). Conclusions The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.
UR - http://hdl.handle.net/10447/345127
M3 - Article
VL - 172
SP - 1613
EP - 1620
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
ER -