Abstract

Introduction. Hemorrhagic transformation (HT), a complication of ischemic stroke (IS) is supposed to influence patient’s prognosis. Aim of our study was to evaluate, in a hospital-based series of patients not treated with thrombolysis, the relationship between HT and late mortality. Methods. Mortality of individuals with spontaneous HT was compared to that of individuals without. Medical records of patients diagnosed with anterior IS during the period 2004-2006 were reviewed. Living status was obtained from the public record office of the municipality of Palermo or indirectly by telephone interview. Outcome measure was 90 days survival after IS onset. Kaplan-Meier estimates were used to construct survival curves. Cox proportional hazards model was used in a univariate analysis to estimate RR for the main outcome measure (death) in the different strata. We evaluated the relationship between HT and the main mortality risk factors. HT was stratified in hemorrhagic infarction (HI) and parenchymal hematoma (PH). Results. Living status was determined for 96.7%. At 3 month follow-up, mortality rate was 12.1% (28/232). At multivariate analysis, large infarct size (OR 2.7, 95% CI 1.2, 6.0, p=0.02) and HT (OR 2.3, 95% CI 1.0, 5.4, p = 0.05) were significantly associated with increased mortality. Parenchymal hematoma was the strongest independent risk factor for late mortality (OR 7.9, 95% CI 2.9, 21.4, p < 0.0001). Conclusions. Infarct size and HT play a significant role in late mortality after IS. Parenchymal hematoma is the strongest predictor of late mortality.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2012

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Stroke
Mortality
Hematoma
Outcome Assessment (Health Care)
Survival
Kaplan-Meier Estimate
Proportional Hazards Models
Infarction
Medical Records
Multivariate Analysis
Interviews

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@conference{15b561d0b76a4123b48f851f21da0480,
title = "LATE MORTALITY OF HEMORRHAGIC TRANSFORMATION OF ISCHEMIC STROKE",
abstract = "Introduction. Hemorrhagic transformation (HT), a complication of ischemic stroke (IS) is supposed to influence patient’s prognosis. Aim of our study was to evaluate, in a hospital-based series of patients not treated with thrombolysis, the relationship between HT and late mortality. Methods. Mortality of individuals with spontaneous HT was compared to that of individuals without. Medical records of patients diagnosed with anterior IS during the period 2004-2006 were reviewed. Living status was obtained from the public record office of the municipality of Palermo or indirectly by telephone interview. Outcome measure was 90 days survival after IS onset. Kaplan-Meier estimates were used to construct survival curves. Cox proportional hazards model was used in a univariate analysis to estimate RR for the main outcome measure (death) in the different strata. We evaluated the relationship between HT and the main mortality risk factors. HT was stratified in hemorrhagic infarction (HI) and parenchymal hematoma (PH). Results. Living status was determined for 96.7{\%}. At 3 month follow-up, mortality rate was 12.1{\%} (28/232). At multivariate analysis, large infarct size (OR 2.7, 95{\%} CI 1.2, 6.0, p=0.02) and HT (OR 2.3, 95{\%} CI 1.0, 5.4, p = 0.05) were significantly associated with increased mortality. Parenchymal hematoma was the strongest independent risk factor for late mortality (OR 7.9, 95{\%} CI 2.9, 21.4, p < 0.0001). Conclusions. Infarct size and HT play a significant role in late mortality after IS. Parenchymal hematoma is the strongest predictor of late mortality.",
author = "Giovanni Savettieri and Marco D'Amelio and Paolo Ragonese and Valeria Terruso and Sabrina Realmuto and Francesca Valentino and Giorgia Famoso and Paolo Aridon",
year = "2012",
language = "English",

}

TY - CONF

T1 - LATE MORTALITY OF HEMORRHAGIC TRANSFORMATION OF ISCHEMIC STROKE

AU - Savettieri, Giovanni

AU - D'Amelio, Marco

AU - Ragonese, Paolo

AU - Terruso, Valeria

AU - Realmuto, Sabrina

AU - Valentino, Francesca

AU - Famoso, Giorgia

AU - Aridon, Paolo

PY - 2012

Y1 - 2012

N2 - Introduction. Hemorrhagic transformation (HT), a complication of ischemic stroke (IS) is supposed to influence patient’s prognosis. Aim of our study was to evaluate, in a hospital-based series of patients not treated with thrombolysis, the relationship between HT and late mortality. Methods. Mortality of individuals with spontaneous HT was compared to that of individuals without. Medical records of patients diagnosed with anterior IS during the period 2004-2006 were reviewed. Living status was obtained from the public record office of the municipality of Palermo or indirectly by telephone interview. Outcome measure was 90 days survival after IS onset. Kaplan-Meier estimates were used to construct survival curves. Cox proportional hazards model was used in a univariate analysis to estimate RR for the main outcome measure (death) in the different strata. We evaluated the relationship between HT and the main mortality risk factors. HT was stratified in hemorrhagic infarction (HI) and parenchymal hematoma (PH). Results. Living status was determined for 96.7%. At 3 month follow-up, mortality rate was 12.1% (28/232). At multivariate analysis, large infarct size (OR 2.7, 95% CI 1.2, 6.0, p=0.02) and HT (OR 2.3, 95% CI 1.0, 5.4, p = 0.05) were significantly associated with increased mortality. Parenchymal hematoma was the strongest independent risk factor for late mortality (OR 7.9, 95% CI 2.9, 21.4, p < 0.0001). Conclusions. Infarct size and HT play a significant role in late mortality after IS. Parenchymal hematoma is the strongest predictor of late mortality.

AB - Introduction. Hemorrhagic transformation (HT), a complication of ischemic stroke (IS) is supposed to influence patient’s prognosis. Aim of our study was to evaluate, in a hospital-based series of patients not treated with thrombolysis, the relationship between HT and late mortality. Methods. Mortality of individuals with spontaneous HT was compared to that of individuals without. Medical records of patients diagnosed with anterior IS during the period 2004-2006 were reviewed. Living status was obtained from the public record office of the municipality of Palermo or indirectly by telephone interview. Outcome measure was 90 days survival after IS onset. Kaplan-Meier estimates were used to construct survival curves. Cox proportional hazards model was used in a univariate analysis to estimate RR for the main outcome measure (death) in the different strata. We evaluated the relationship between HT and the main mortality risk factors. HT was stratified in hemorrhagic infarction (HI) and parenchymal hematoma (PH). Results. Living status was determined for 96.7%. At 3 month follow-up, mortality rate was 12.1% (28/232). At multivariate analysis, large infarct size (OR 2.7, 95% CI 1.2, 6.0, p=0.02) and HT (OR 2.3, 95% CI 1.0, 5.4, p = 0.05) were significantly associated with increased mortality. Parenchymal hematoma was the strongest independent risk factor for late mortality (OR 7.9, 95% CI 2.9, 21.4, p < 0.0001). Conclusions. Infarct size and HT play a significant role in late mortality after IS. Parenchymal hematoma is the strongest predictor of late mortality.

UR - http://hdl.handle.net/10447/72701

M3 - Paper

ER -