TY - JOUR
T1 - LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ONDEFINITIONS AND DETERMINANTS
AU - Giuffre, Mario
AU - Corsello, Giovanni
AU - Piro, Ettore
AU - Serra, Gregorio
AU - Corsello, Giovanni
AU - Serra, Gregorio
AU - Schierz, Ingrid Anne Mandy
AU - Antona, Vincenzo
AU - Piro, Ettore
AU - Giuffrè, Mario
AU - Schierz, Ingrid Anne Mandy
AU - Antona, Vincenzo
PY - 2020
Y1 - 2020
N2 - Human growth and development, starting from conception, are characterized by a progressiveincrease in body and organ dimensions, as well as specific functional maturity, under the influenceof genetic as well as environmental and epigenetic determinants. Beyond a possible normal familialtrait, increased fetal growth resulting in a large for gestational age newborn, isolated macrosomia orthat associated with congenital malformation, can be attributable to both maternal metabolic andgenetic pathology. Overgrowth syndromes are a heterogeneous group of diseases characterized byexcessive tissue development often concomitant to neurodevelopmental involvement. Recently, anincreased risk of fetal overgrowth with Assisted Reproductive Technology has been reported. Thus,in pediatric practice, it is fundamental to monitor any patient who presents with increased growthparameters, variable malformations, neurodevelopmental delay, and distinctive features from birth,aiming to ensure as adequate a medical management as possible, and for some of the disorders,strict tumor monitoring is also necessary.
AB - Human growth and development, starting from conception, are characterized by a progressiveincrease in body and organ dimensions, as well as specific functional maturity, under the influenceof genetic as well as environmental and epigenetic determinants. Beyond a possible normal familialtrait, increased fetal growth resulting in a large for gestational age newborn, isolated macrosomia orthat associated with congenital malformation, can be attributable to both maternal metabolic andgenetic pathology. Overgrowth syndromes are a heterogeneous group of diseases characterized byexcessive tissue development often concomitant to neurodevelopmental involvement. Recently, anincreased risk of fetal overgrowth with Assisted Reproductive Technology has been reported. Thus,in pediatric practice, it is fundamental to monitor any patient who presents with increased growthparameters, variable malformations, neurodevelopmental delay, and distinctive features from birth,aiming to ensure as adequate a medical management as possible, and for some of the disorders,strict tumor monitoring is also necessary.
UR - http://hdl.handle.net/10447/429309
M3 - Article
JO - EuroMediterranean Biomedical Journal
JF - EuroMediterranean Biomedical Journal
SN - 2279-7165
ER -