Kinetics of in vivo inhibition of tissue cathepsin d by pepstatin A

Nicolo' Gebbia, Gaetano Leto, Francesca Maria Tumminello, Nicola Gebbia, Gaetano Leto, Luciano Rausa, Luciano Rausa

Risultato della ricerca: Articlepeer review

8 Citazioni (Scopus)

Abstract

1. 1. We have investigated the kinetics of inhibition of cathepsin D in heart, liver and skeletal muscle of CD-1 mice following administration of 25, 50, 100 and 200 mg/kg i.p. of pepstatin A, a specific inhibitor of this protease. 2. 2. In the liver, a significant inhibition of cathepsin D occurred up to at least 15 days, whereas, in heart and skeletal muscle, this inhibition lasted for a much shorter period of time. 3. 3. These results show that the recovery of enzyme activity to normal values is dose-dependent and that, at the same dose level, marked differences occur in the recovery of enzyme activity in these organ tissues, the liver being the most sensitive one. © 1988.
Lingua originaleEnglish
pagine (da-a)917-920
Numero di pagine4
RivistaInternational Journal of Biochemistry
Volume20
Stato di pubblicazionePublished - 1988

All Science Journal Classification (ASJC) codes

  • Biochemistry

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