Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study

Crocettarachele Sartorio, Caterina La Cascia, Giada Tripoli, Daniele La Barbera, Fabio Seminerio, Laura Ferraro, Marta Di Forti, Ilaria Tarricone, Robin M. Murray, Charlotte Gayer-Anderson, Craig Morgan, Manuel Arrojo, Julio Sanjuán, James B. Kirkbride, Peter B. Jones, Jose Luis Santos, Jim Van Os, Eva Velthorst, Miguel Bernardo, Alex RichardsAntonio Lasalvia, Giada Tripoli, Hannah E. Jongsma, Graham K. Murray, Victoria Rodriguez, Cristina Marta Del-Ben, Domenico Berardi, Pak C. Sham, Andrea Tortelli, Celso Arango, Bart P.F. Rutten, Pierre-Michel Llorca, Jean-Paul Selten, Paulo Rossi Menezes, Lieuwe De Haan, Julio Bobes, Andrei Szöke, Michael O'Donovan, Sarah Tosato, Diego Quattrone

Risultato della ricerca: Article

Abstract

Background The ‘jumping to conclusions’ (JTC) bias is associated with both psychosis and general cognition but their relationship is unclear. In this study, we set out to clarify the relationship between the JTC bias, IQ, psychosis and polygenic liability to schizophrenia and IQ. Methods A total of 817 first episode psychosis patients and 1294 population-based controls completed assessments of general intelligence (IQ), and JTC, and provided blood or saliva samples from which we extracted DNA and computed polygenic risk scores for IQ and schizophrenia. Results The estimated proportion of the total effect of case/control differences on JTC mediated by IQ was 79%. Schizophrenia polygenic risk score was non-significantly associated with a higher number of beads drawn ( B = 0.47, 95% CI −0.21 to 1.16, p = 0.17); whereas IQ PRS ( B = 0.51, 95% CI 0.25–0.76, p < 0.001) significantly predicted the number of beads drawn, and was thus associated with reduced JTC bias. The JTC was more strongly associated with the higher level of psychotic-like experiences (PLEs) in controls, including after controlling for IQ ( B = −1.7, 95% CI −2.8 to −0.5, p = 0.006), but did not relate to delusions in patients. Conclusions Our findings suggest that the JTC reasoning bias in psychosis might not be a specific cognitive deficit but rather a manifestation or consequence, of general cognitive impairment. Whereas, in the general population, the JTC bias is related to PLEs, independent of IQ. The work has the potential to inform interventions targeting cognitive biases in early psychosis.
Lingua originaleEnglish
pagine (da-a)1-11-11
Numero di pagine11
RivistaPsychological Medicine
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

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    Sartorio, C., La Cascia, C., Tripoli, G., La Barbera, D., Seminerio, F., Ferraro, L., Di Forti, M., Tarricone, I., Murray, R. M., Gayer-Anderson, C., Morgan, C., Arrojo, M., Sanjuán, J., Kirkbride, J. B., Jones, P. B., Santos, J. L., Os, J. V., Velthorst, E., Bernardo, M., ... Quattrone, D. (2020). Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study. Psychological Medicine, 1-11-11.