Is the Serum N Terminal Pro-Brain Natriuretic Peptide theBest Candidate Biomarker for Long-term Prognosis in Patients withProsthesis-patient Mismatch after Mitral Valve Replacement?

Risultato della ricerca: Otherpeer review

Abstract

AGE8. Is the Serum N Terminal Pro-Brain Natriuretic Peptide theBest Candidate Biomarker for Long-term Prognosis in Patients withProsthesis-patient Mismatch after Mitral Valve Replacement?C. R. Balistreri1, C. Pisano1, R. Franchino1, S.R. Vacirca1, F. Crapanzano1,O. F. Triolo1, C. Palmeri1, G. Ruvolo11University Of Palermo, Palermo, ItalyBackground: Natriuretic peptides (NPs) are released from the heart inresponse to pressure and volume overload. Among these, B-NP and Nterminal-proBNP (NT-proBNP) have become important diagnostic tools forthe management of heart failure. However, B-NP and NT-proBNP levelsreflect complications of systolic and diastolic function as well as alterationof right ventricular and valvular function. In addition, their serum levelshave a prognostic value in multiple clinical settings. Based on theseobservations, we sought to evaluate the relationship between prosthesispatient mismatch (PPM) and serum NT-pro-BNP levels after mitral valvereplacement (MVR). PPM following MVR has been less investigated and itseems to mediate deleterious effects on long-term survival, even ifcontrasting opinions and data exist in the literature.Methods: A total of 100 patients that have undergone this surgicaltreatment will be enrolled, and opportune clinical data and peripheralblood samples will be collected. Blood samples are utilized to analyzeclinical conditions and serum NT-proBNP levels. Evaluation ofhemodynamic performances before or under dobutamine infusion is alsobeing assessed.Results: The preliminary data on the serum NT-proBNP levels obtainedseem to be interesting and promising, as well as their correlations withhemodynamic performances.Conclusions: The demonstration of negative effects on tricuspid valveand pulmonary hypertension and consequently on survival induced byPPM after MVR through the serum quantification of NT-proBNP levelsmight lead to consider it as an optimal biomarker to evaluate patients’long-term prognosis and optimize surgical recommendations (i.e. tricuspidvalve repair during mitral valve surgery in patients with moderate-severemismatch).
Lingua originaleEnglish
Pagine12-12
Numero di pagine1
Stato di pubblicazionePublished - 2014

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