Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 170-173 |
| Numero di pagine | 4 |
| Rivista | Rejuvenation Research |
| Volume | 15 |
| Stato di pubblicazione | Published - 2012 |
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All Science Journal Classification (ASJC) codes
- Ageing
- Geriatrics and Gerontology
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Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm? Data from a preliminary study. / Merlo, D; Colonna-Romano, G; Candore G; Ruvolo, G.
In: Rejuvenation Research, Vol. 15, 2012, pag. 170-173.Risultato della ricerca: Article
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TY - JOUR
T1 - Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm? Data from a preliminary study
AU - Merlo, D; Colonna-Romano, G; Candore G; Ruvolo, G
AU - Colonna Romano, Giuseppina
AU - Candore, Giuseppina
AU - Fattouch, Khalil
AU - Incalcaterra, Egle
AU - Pisano, Calogera
AU - Balistreri, Carmela Rita
AU - Caruso, Marco
PY - 2012
Y1 - 2012
N2 - Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA–protein structures at the ends of chromosome with remarkable functions—preventing their recognition as double-stranded DNA breaks, protecting their recombination and degradation, and avoiding a DNA damage cellular response. Telomere shortening is currently considered the best aging marker, but is also a predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be a better predictor of vascular risk rather than chronological age. This concept is supported by key assumptions that peripheral blood leukocyte telomere content accurately reflects that of the vascular wall and its decrease is associated with premature vascular disease. Thus, we are analyzing whether the mean of blood leukocyte telomere length might also be a predictor for sporadic thoracic aortic aneurysm (S-TAA). The preliminary results seem to be promising. Shorter telomeres were detected in patients than in controls. Thus, mean of blood leukocyte telomere length could contribute to identify individuals at S-TAA risk.
AB - Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA–protein structures at the ends of chromosome with remarkable functions—preventing their recognition as double-stranded DNA breaks, protecting their recombination and degradation, and avoiding a DNA damage cellular response. Telomere shortening is currently considered the best aging marker, but is also a predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be a better predictor of vascular risk rather than chronological age. This concept is supported by key assumptions that peripheral blood leukocyte telomere content accurately reflects that of the vascular wall and its decrease is associated with premature vascular disease. Thus, we are analyzing whether the mean of blood leukocyte telomere length might also be a predictor for sporadic thoracic aortic aneurysm (S-TAA). The preliminary results seem to be promising. Shorter telomeres were detected in patients than in controls. Thus, mean of blood leukocyte telomere length could contribute to identify individuals at S-TAA risk.
UR - http://hdl.handle.net/10447/73478
M3 - Article
VL - 15
SP - 170
EP - 173
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
ER -