Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm? Data from a preliminary study

Merlo, D; Colonna-Romano, G; Candore G; Ruvolo, G

Risultato della ricerca: Article

19 Citazioni (Scopus)

Abstract

Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA–protein structures at the ends of chromosome with remarkable functions—preventing their recognition as double-stranded DNA breaks, protecting their recombination and degradation, and avoiding a DNA damage cellular response. Telomere shortening is currently considered the best aging marker, but is also a predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be a better predictor of vascular risk rather than chronological age. This concept is supported by key assumptions that peripheral blood leukocyte telomere content accurately reflects that of the vascular wall and its decrease is associated with premature vascular disease. Thus, we are analyzing whether the mean of blood leukocyte telomere length might also be a predictor for sporadic thoracic aortic aneurysm (S-TAA). The preliminary results seem to be promising. Shorter telomeres were detected in patients than in controls. Thus, mean of blood leukocyte telomere length could contribute to identify individuals at S-TAA risk.
Lingua originaleEnglish
pagine (da-a)170-173
Numero di pagine4
RivistaRejuvenation Research
Volume15
Stato di pubblicazionePublished - 2012

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Thoracic Aortic Aneurysm
Telomere
Leukocytes
Blood Vessels
Telomere Shortening
Double-Stranded DNA Breaks
Cell Aging
Vascular Diseases
Genetic Recombination
Cardiovascular Diseases
Chromosomes
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

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Is the mean blood leukocyte telomere length a predictor for sporadic thoracic aortic aneurysm? Data from a preliminary study. / Merlo, D; Colonna-Romano, G; Candore G; Ruvolo, G.

In: Rejuvenation Research, Vol. 15, 2012, pag. 170-173.

Risultato della ricerca: Article

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abstract = "Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA–protein structures at the ends of chromosome with remarkable functions—preventing their recognition as double-stranded DNA breaks, protecting their recombination and degradation, and avoiding a DNA damage cellular response. Telomere shortening is currently considered the best aging marker, but is also a predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be a better predictor of vascular risk rather than chronological age. This concept is supported by key assumptions that peripheral blood leukocyte telomere content accurately reflects that of the vascular wall and its decrease is associated with premature vascular disease. Thus, we are analyzing whether the mean of blood leukocyte telomere length might also be a predictor for sporadic thoracic aortic aneurysm (S-TAA). The preliminary results seem to be promising. Shorter telomeres were detected in patients than in controls. Thus, mean of blood leukocyte telomere length could contribute to identify individuals at S-TAA risk.",
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AU - Merlo, D; Colonna-Romano, G; Candore G; Ruvolo, G

AU - Colonna Romano, Giuseppina

AU - Candore, Giuseppina

AU - Fattouch, Khalil

AU - Incalcaterra, Egle

AU - Pisano, Calogera

AU - Balistreri, Carmela Rita

AU - Caruso, Marco

PY - 2012

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AB - Telomeres have been postulated as a universal clock that shortens in parallel with cellular aging. They are specialized DNA–protein structures at the ends of chromosome with remarkable functions—preventing their recognition as double-stranded DNA breaks, protecting their recombination and degradation, and avoiding a DNA damage cellular response. Telomere shortening is currently considered the best aging marker, but is also a predictor for age-related diseases, including cardiovascular diseases. Biological age clearly seems to be a better predictor of vascular risk rather than chronological age. This concept is supported by key assumptions that peripheral blood leukocyte telomere content accurately reflects that of the vascular wall and its decrease is associated with premature vascular disease. Thus, we are analyzing whether the mean of blood leukocyte telomere length might also be a predictor for sporadic thoracic aortic aneurysm (S-TAA). The preliminary results seem to be promising. Shorter telomeres were detected in patients than in controls. Thus, mean of blood leukocyte telomere length could contribute to identify individuals at S-TAA risk.

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