Is Italian population protected from Poliovirus? Results of a seroprevalence survey in Florence, Italy

Giovanni Giammanco, Simona De Grazia, Irene Bellini, Antonino Nastasi, Sara Boccalini, Angela Bechini, Emilia Tiscione, Floriana Bonura, Noemi Urone

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)

Abstract

Objectives: Periodical assessments of population susceptibility to polioviruses (PV) is essential for evaluating population protection and planning appropriate vaccination strategies. The aim of the current work was to assess serological protective titers against all three polioviruses in the general population of Florence. Methods: A convenience sample of 328 sera, collected in 2009 in Florence (Central Italy) was analyzed. Samples were considered protective if neutralizing antibodies were detected at dilutions ≥1:8, according to the WHO protocols. Results: The immune coverage was 75.3%, 69.2% and 46% for PV1, PV2 and PV3, respectively. The protective titers of neutralizing antibodies were generally higher in children up to 14 years of age, with 74.4% (PV1), 75.6% (PV2) and 56.7% (PV3) of seroprevalence. From the age of 11 years, most of the study subjects were seronegative for PV3. Conclusions: In a polio-free country with strong migration pressures, such as Italy, our results bring clear support to the recent recommendation of Italian health authorities to introduce a fifth dose of IPV vaccine in adolescence all over the country.
Lingua originaleEnglish
pagine (da-a)2248-2253
Numero di pagine6
RivistaHUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume14
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Fingerprint Entra nei temi di ricerca di 'Is Italian population protected from Poliovirus? Results of a seroprevalence survey in Florence, Italy'. Insieme formano una fingerprint unica.

Cita questo